Why doesn't APAP respond to apneas?

General Discussion on any topic relating to CPAP and/or Sleep Apnea.
User avatar
StillAnotherGuest
Posts: 1005
Joined: Sun Sep 24, 2006 6:43 pm

Don't Be Doin' A Yossarian...

Post by StillAnotherGuest » Mon Nov 03, 2008 5:52 am

OutaSync wrote:So what is periodic breathing, anyway? And why is it bad? Or how bad is it?
-SWS wrote:
Respironics Sales Sheet wrote:Periodic breathing is defined as alternating periods of hyperventilation with waxing/waning tidal volume and periods of central hypopneas or apneas.
http://www.respironics.com/UserGuides/B ... 042299.pdf

That hyperventilation causes pulmonary over-ventilation or respiratory "overshoot". That in turn tends to cause those ensuing central hypopneas or apneas.
The key point there is that periodic breathing is purely central, whereas CompSAS is combo.

However, in re:
-SWS wrote:Image

So on CPAP at 14 cm, we see some "machine-scored" periodic breathing. None of the OSA machines have data sets that are even capable of revealing that extremely essential SDB clue. Home-machine data bashers: please don't throw that clue out as if it were an artifact. It corroborates the central emergence shown on Bev's NPSG---and a variety of other essential SDB clues presented here as well.
2 isolated instances of PB composing 0% of the night is nothing to lose any sleep over. Knowing you like I do, I'd say those areas are either mixed or sleep-onset phenomena.

Or artifact.

SAG
Image

Aromatherapy may help CPAP compliance. Lavender, Mandarin, Chamomile, and Sweet Marjoram aid in relaxation and sleep. Nature's Gift has these and a blend of all four called SleepEase.

User avatar
OutaSync
Posts: 2048
Joined: Sun Sep 23, 2007 8:49 am
Location: Virginia

Re: Why doesn't APAP respond to apneas?

Post by OutaSync » Mon Nov 03, 2008 6:48 am

Then, how does periodic breathing compare with variable breathing, as shown in Encore Pro Analyzer?

Image


Bev
Diagnosed 9/4/07
Sleep Study Titrated to 19 cm H2O
Rotating between Activa and Softgel
11/2/07 RemStar M Series Auto with AFlex 14-17
10/17/08 BiPAP Auto SV 13/13-23, BPM Auto, AHI avg <1

-SWS
Posts: 5301
Joined: Tue Jan 11, 2005 7:06 pm

Re: Why doesn't APAP respond to apneas?

Post by -SWS » Mon Nov 03, 2008 7:01 am

SAG wrote:The key point there is that periodic breathing is purely central, whereas CompSAS is combo.
However, CompSA typically entails periodic breathing in NREM.

My eralier point in the thread is that Bev displays some clear signs of CompSA/CSDB, and those patients are the ones reported to experience greater sleep-related biologic discomfort and daytime symptoms. Her scoring of PB only corroborates all that IMO.

Bev, periodic breathing will get relegated to that variable breathing category on the OSA-targeted APAP machines by Respironics. Quite a few other variable-breathing conditions, such as REM, wakefulness, etc. can get relegated to that category as well. However, your variable breathing percentages on those charts don't look dissimilar to many Encore reports that have been presented.

User avatar
StillAnotherGuest
Posts: 1005
Joined: Sun Sep 24, 2006 6:43 pm

Re: Why doesn't APAP respond to apneas?

Post by StillAnotherGuest » Mon Nov 03, 2008 7:31 am

Bev:

Can you make a VB Report on the days you were on the AutoSV?

SAG
Image

Aromatherapy may help CPAP compliance. Lavender, Mandarin, Chamomile, and Sweet Marjoram aid in relaxation and sleep. Nature's Gift has these and a blend of all four called SleepEase.

User avatar
StillAnotherGuest
Posts: 1005
Joined: Sun Sep 24, 2006 6:43 pm

Re: Why doesn't APAP respond to apneas?

Post by StillAnotherGuest » Mon Nov 03, 2008 7:41 am

No, I don't think so because the Apnea/Hypopnea Control Layer supercedes the Variable Breathing Control Layer and should have registered something first. In Variable Breathing, one is assumed to be "breathing".

SAG
Image

Aromatherapy may help CPAP compliance. Lavender, Mandarin, Chamomile, and Sweet Marjoram aid in relaxation and sleep. Nature's Gift has these and a blend of all four called SleepEase.

User avatar
Snoredog
Posts: 6399
Joined: Sun Mar 19, 2006 5:09 pm

Re: Why doesn't APAP respond to apneas?

Post by Snoredog » Mon Nov 03, 2008 8:36 am

Since Normal breathing is controlled by the CO2 level in the blood, if we look at Bev's Encore report, obviously that is a Ramp period in the beginning from 10 cm to 14 cm, and nothing shows up until after therapy hour 2 (SAG: how can that be onset events 2 hrs into therapy?),
but it seems she starts off with Apnea Period which would lower Oxygen level and Increase CO2 level, body tries to recover with Periodic Breathing which overshoots tidal or exhale which then turns into Central Dysregulation. We cannot actually see that happen because it wasn't set up to go to any backup mode, or at least that is the way I read that last report.

Summary of events seen on last Encore above:
1. Appears to start as Obstructive apnea which leads to increased CO2
2. Upon recovery from the apnea she goes into Periodic Breathing (would seem same as Hyperventilation)
3. She overshoots recovery and goes into Central Dysregulation (cluster of AP after the PB).

Obviously:

We want to avoid the obstructive Apnea. However, I suspect she is also a shallow breather, meaning that would essentially result in the same action as shown above with an obstructive event. This would play out as:

1. Shallow breathing to the point of a showing up on the Encore report as a apnea (central),
2. Upon recovery from the central she goes into Periodic Breathing (would appear same as Hyperventilation)
3. She again overshoots recovery and goes into Central Dysregulation (cluster of AP after the PB).

This shallow breathing essentially becomes so shallow no oxygen is taken in, CO2 level increases, same fight or flight response is seen. I can duplicate this over and over at will simply by taking a nap without the machine. I think if you can find the SV settings to prevent the shallow breathing you can resolve this.

Note: Shallow breathing would also confirm WHY in SV mode the machine was going nutso and maxing out IPAP working pressure. It seen that inspiration peak NOT being met, so it ramped up IPAP.
someday science will catch up to what I'm saying...

User avatar
OutaSync
Posts: 2048
Joined: Sun Sep 23, 2007 8:49 am
Location: Virginia

Re: Why doesn't APAP respond to apneas?

Post by OutaSync » Mon Nov 03, 2008 9:09 am

SAG,

I don't think the Encore Analyzer works with the SV. I'm at work now, so can't try it.

Bev
Diagnosed 9/4/07
Sleep Study Titrated to 19 cm H2O
Rotating between Activa and Softgel
11/2/07 RemStar M Series Auto with AFlex 14-17
10/17/08 BiPAP Auto SV 13/13-23, BPM Auto, AHI avg <1

User avatar
StillAnotherGuest
Posts: 1005
Joined: Sun Sep 24, 2006 6:43 pm

NM

Post by StillAnotherGuest » Mon Nov 03, 2008 6:48 pm

OutaSync wrote:I don't think the Encore Analyzer works with the SV. I'm at work now, so can't try it.
I looked at an AutoSV file and the Variable Breathing parameter isn't even listed, so James' program won't pick up anything even if it is compatible. I think the VB Layer simply morphed into the PB Layer.

Not that the VB Layer would be actually able to do anything anyway. You can't instantly respond and suspend activity at the same time.

SAG
Image

Aromatherapy may help CPAP compliance. Lavender, Mandarin, Chamomile, and Sweet Marjoram aid in relaxation and sleep. Nature's Gift has these and a blend of all four called SleepEase.

User avatar
dsm
Posts: 6996
Joined: Mon Jun 20, 2005 6:53 am
Location: Near the coast.

Re: Why doesn't APAP respond to apneas?

Post by dsm » Mon Nov 03, 2008 8:27 pm

Periodic Breathing - what are we meaning ? - just asking this because I have thought that there was no adequate definition of what it means in Bev's thread.

I sometimes see red PB scores in my nights data from the Bipap SV (posted one here a week or so back) but I have never been concerned because they are so small in terms of the whole night's data. Perhaps if I saw a chart with 20 or 30 PB red marks I might begin to consider the data is saying something. The Resp presentations talk about PB as the 'waxing & waning' volume & Bev's data seemed to show that but her volume was erratic rather than a pattern or cyclic like Cheynes_Stokes resp is.

However on both Bev's and my charts, the SV pressure support gets exercised regularly (in mycase in small periods of a few mins, in Bev's for long periods) - does that constitute periodic breathing ?. If yes then how does that relate to the red score marks in both our charts on the SV ?.

I understand that in the Respironics AUTO the machine considers Variable Breathing as fluctuating volume & its algorithm tries increasing pressure in small steps & if that doesn't produce an improvement it reverses & drops pressure in small steps & if that doesn't produce an improvement it stops trying for a set period.

Has anyone got a clearer (consistent across brands) definition of Periodic Breathing that isn't specifically describing Cheynes-Stokes respiration. If not, then I am thinking that neither Bev nor I have clear examples of PB.

DSM
xPAP and Quattro std mask (plus a pad-a-cheek anti-leak strap)

User avatar
StillAnotherGuest
Posts: 1005
Joined: Sun Sep 24, 2006 6:43 pm

VBabble (Revisited)

Post by StillAnotherGuest » Tue Nov 04, 2008 5:38 am

-SWS wrote:...your variable breathing percentages on those charts don't look dissimilar to many Encore reports that have been presented.
However, since nobody here can be considered "normal", I would conclude that that observation means that this is an abnormal result.

I would like to create a "Living Document" to determine an interpretive strategy for the variable breathing (VB) parameter, and would like to start out with:

< 5.0% Normal
5 - 15% Mild Disturbance
15 - 25% Moderate Disturbance
> 25% Severe Disturbance

I know one person, whom I consider to be quite "normal", with a VB of 0%.

And this would put some of dilfo's values in a different dimension.

In an update of an earlier post.......

I would say the contributors to the VB are:

Normal variation (REM sleep, normal wake periods)
Abnormal variation (insomnia, wake/1 transition, arousals from non-respiratory events)
Whatever the VB criteria actually is.
Criteria when it can't kick in (the algorithm hierarchy seems to say that if there are leaks, snores, or apnea/hypopnea, you can't enter Variable Breathing Mode (VBM)(I just made that up, too)(the acronym, not the hierarchy). That's why I believe Periodic Breathing, when there are apneas, would not be relegated to the VB Bucket.

BTW, in a limited study of Periodic Breathers (one) analyzed by Encore 1.8.49 (not the current version recommended for AutoSV) the reported value of PB appeared to be low relative to the clinical situation. But until somebody can cough up the actual algorithm, I don't think anybody should put the mortgage down on the table at the Indian place on what they think the PB% means.

VB is not necessarily related to variable breathing per se, but rather the machine is in VBM. It has seen some erratic breathing and has suspended titration mode. Whether the erratic events are continuous or not is not known.

The basic goal of VBM seems to move the patients back to the setting that was in effect before the onset of erratic breathing. In both APAP and AutoBiPAP, this is accomplished slowly, at a rate of 0.5 cmH2O/minute, up to 2.0 cmH2O (using IPAP in AutoBiPAP, affecting EPAP only if an IPAP change would necessitate an EPAP change because of PS restrictions). Also, pressure changes are tempered based on the presence or absence of snoring prior to the initiation of VBM.

If you could match up VB Mode to time that would be extremely helpful, but I think you can only view VB vs Pressure.

REM sleep in adults is generally pretty stable, at least stable enough that if you see 25% VB you shouldn't think it's all REM. I mean, there may be a little variation, but I think the point of considering VB in REM is that you don't want to poke at it at all with unnecessary pressure changes.

If your NPSG shows decreased sleep efficiency, increased stage shifts (especially Stage 1), increased spontaneous AI and/or increased PLM AI, Ihen I would think those would be the most likely suspects.

In a basic edit of the mechanics of VBM from the patent ("VBPC Lite", so that ol' SFB Mike can understand this)(but this might not even be what's in there now):

Variable Breathing Pressure Control

Once the variable breathing controller has been granted control of the pressure support system, it takes some initial action based on the action the auto-CPAP controller is taking. After this initial action, it performs an independent pressure control operation.

A prior pressure that is flat will cause the pressure delivered to the patient to remain at that level.

A prior pressure that is increasing will cause the variable breathing controller to initially decrease the pressure delivered to the patient at a rate of 0.5 cmH2O per minute. The magnitude of the decrease is dependent on the magnitude of the increase in prior pressure. The pressure decrease is intended to erase the prior pressure increase that possibly caused the variable breathing. However, the total decrease in pressure drop is limited to 2 cmH2O. After pressure decrease, the variable breathing controller holds the pressure steady.

A prior pressure that is decreasing will cause the variable breathing controller to initially increase the pressure delivered to the patient at a rate of 0.5 cmH2O per minute. The magnitude of the increase is dependent on the magnitude of the decrease in prior pressure. The pressure increase is intended to erase the prior pressure decrease that may have caused the variable breathing. However, the total increase in pressure is limited to 2 cmH2O. After pressure increase, variable breathing controller holds the pressure steady.

The pressure curve is provided for 5 minutes or until the variable breathing condition clears. Thereafter, the pressure is controlled according to the following:

The pressure is either maintained at a constant value, or it follows a decrease and hold pattern. The decision to hold the pressure or to decrease the pressure is made by comparing the current pressure with the snore treatment pressure. It is to be understood, however, that this duration can be varied over a range of durations.

If there is no snore treatment pressure stored in the system, which will be the case if the snore controller has not been activated, the pressure is held constant. If there is a snore treatment pressure, and if the current pressure is more than a predetermined amount above this snore treatment pressure, such as more than 2 cmH2O above the snore treatment pressure, the variable breathing controller decreases the pressure to a level that is a predetermined amount higher than the snore treatment pressure and holds the pressure at the lower level. The pressure decreases to the snore treatment pressure +1 cmH2O.

The duration during which pressure is provided according to the paradigms discussed above for region is set to 15 minutes or until the variable breathing condition clears. It is to be understood, however, that this 15 minute duration can be varied over a range of durations.


SAG
Image

Aromatherapy may help CPAP compliance. Lavender, Mandarin, Chamomile, and Sweet Marjoram aid in relaxation and sleep. Nature's Gift has these and a blend of all four called SleepEase.

User avatar
travismcgee
Posts: 93
Joined: Mon Jan 07, 2008 7:28 am
Location: minnesota

Re: Why doesn't APAP respond to apneas?

Post by travismcgee » Tue Nov 04, 2008 1:44 pm

Bev, my question is geared toward your taking Ambien to get to sleep, have you ever had your thyroid hormone levels checked?
Hypothyroidism can contribute to insomnia as well as anxiety. The reason I ask is I am going through that very scenario. My TSH
(thyroid stimulating hormone) data over the last 18 months looks like a drawing of mountains and valleys, very unstable. However, my monthly average
AHI hovers around 0.80 yet I am still very tired during the day and usually wake up 3 - 4 times a night (I have been on APAP for 8 months). I don't know if you have discussed this
in previous posts but I wanted to throw it out there because there just isn't enough information for you to digest in this one.

cheers.


Travis
"The major difference between a thing that might go wrong and a thing that cannot possibly go wrong is that when a thing that cannot possibly go wrong goes wrong it usually turns out to be impossible to get at or repair."

Douglas Adams

User avatar
OutaSync
Posts: 2048
Joined: Sun Sep 23, 2007 8:49 am
Location: Virginia

Re: Why doesn't APAP respond to apneas?

Post by OutaSync » Tue Nov 04, 2008 2:05 pm

Travis,
My GP ran thyroid tests and said everything was "fine". However, when I got a copy of the report, I noticed that my cortisol level was very high. I think that is a stress indicator. Could be caused by sleep problems, or could be causing sleep problems?

When I try to sleep, I doze off, wake up, doze off, wake up, over and over until I am am so frustrated that I cannot sleep for hours. The Ambien gets me past that cycle.

Bev
Diagnosed 9/4/07
Sleep Study Titrated to 19 cm H2O
Rotating between Activa and Softgel
11/2/07 RemStar M Series Auto with AFlex 14-17
10/17/08 BiPAP Auto SV 13/13-23, BPM Auto, AHI avg <1

User avatar
dsm
Posts: 6996
Joined: Mon Jun 20, 2005 6:53 am
Location: Near the coast.

Re: Why doesn't APAP respond to apneas?

Post by dsm » Tue Nov 04, 2008 3:35 pm

On going over the various original comments in this thread and reviewing the data from Bev's Auto & from the SV and from comments from our other learned friends & SAG's post above on PB, it seems to me that Bev's auto data showing those 'chairs' esp when there were no 'events' being scored, was what Respironics term Variable Breathing. As SAG says, Bev does not show any PB that is noteworthy but the erratic rate & volume associated with her sleep scores as Variable Breathing on the AUTO and this same respiration on the SV triggers both rate & pressure support thus the constant periods where IpapCurrent is at IpapMax.

Does Bev have regular centrals ? - I don't think that has been established as conclusive. Bev does have periods of erratic rate & they are what is triggering the 'central' mechanism in the SV machine. The algorithms in most Bilevels and in the SV machine that respond to centrals do so by tracking rate (not volume). The SV does appear (ref SWS) to have a routine that uses the 'puff' technique to try to determine what type of limitation may be occurring but the basic mechanism for managing centrals is tracking the rate & cycling the machine if the rate drops below backup or drops outside the BPM=AUTO tracked rate. Bev's AUTO rate does trigger the SV but when used with a backup rate doesn't seem to trigger it much. I do agree with SWS & the others who have commented that PS (SV pressure support) may be setting off part of Bev's erratic respiration but more likely SV Pressure Support triggers hypercapnia and the resultant sore head the next morning, very predictable.

Bev doesn't show typical signs of hyperventilation (neither the rate not volume appear to suggest any hyperventilation). But as already mentioned Bev does show symptoms of hypercapnia (the headaches when SV PS is activated).

It seems to me to keep coming back to Bev's need for medication & the ongoing anxiety before and during in sleep. Address this & the other problems may just all go away.

A one liner: "The Bipap SV pressure support mechanism is not suited to Bev's current predisposition to erratic rate & fluctuating volume respiration. The result of applying SV PS appears to be hypercapnia & the predictable resulting headaches".

DSM

#2 - an interesting link re MCS - interesting in its association with SA and also Bev's headaces when on SV pressure support
http://www.websciences.org/cftemplate/N ... D=20001413

EXTRACTED ...

The multiple chemical sensitivities syndrome (MCS) and other chronic syndromes causing fatigue, headache and other protean CNS symptoms without observable signs, are proposed to result from hypoxia/hypercapnia (H/H) due to disturbed breathing. The concept is explained in terms of sleep apnea (SA), although H/H could result from causes other than SA. Reasons for considering this etiologic linkage are as follows: 1. MCS symptoms resemble those of SA. 2. The only physical signs associated with MCS (upper airway inflammation and obstruction) can aggravate SA. 3. The only neuropsychiatric finding common among MCS symptomatics, reduced verbal recall, is associated with SA. 4. Many MCS symptomatics attribute onset of their condition to a pesticide or solvent exposure. Solvent neurotoxicity may cause cacosmia, a symptom of MCS and SA. 5. Improved upper airway patency, a first-line therapy in SA, may improve symptoms in some MCS-like conditions. Implications for diagnosis and treatment of MCS are discussed. Copyright 2000 Harcourt Publishers Ltd.
Last edited by dsm on Tue Nov 04, 2008 5:49 pm, edited 5 times in total.
xPAP and Quattro std mask (plus a pad-a-cheek anti-leak strap)

User avatar
echo
Posts: 2400
Joined: Wed Jul 18, 2007 4:20 pm

Re: Why doesn't APAP respond to apneas?

Post by echo » Tue Nov 04, 2008 4:00 pm

Bev, I was thinking - if the Ambien is giving you problems, have you tried other sleeping aids? Sonata (zaleplon) is really good (for me) and doesn't give me that hangover feeling the next day. It has a pretty short half-life, but will work for a minimum of 4 hours. According to a publication (http://www.ncbi.nlm.nih.gov/pubmed/10733619) it does not interfere with sleep architecture (though a post from Titrator lumps it next to Ambien viewtopic.php?f=1&t=484&p=2424&hilit=zaleplon#p2424). It is not specifically meant for prolonged sleep, but it will probably get you through the first 4 hours.

Here's more info on it: http://www.ncbi.nlm.nih.gov/books/bv.fc ... er.a601251

One of my doctors commented that "no one prescribes that anymore", probably because they get paid to prescribe newer meds!
just my 2 cents.
PR System One APAP, 10cm
Activa nasal mask + mouth taping w/ 3M micropore tape + Pap-cap + PADACHEEK + Pur-sleep
Hosehead since 31 July 2007, yippie!

User avatar
OutaSync
Posts: 2048
Joined: Sun Sep 23, 2007 8:49 am
Location: Virginia

Re: Why doesn't APAP respond to apneas?

Post by OutaSync » Tue Nov 04, 2008 7:37 pm

Echo,
Thanks for that info. I haven't tried Sonata. I should ask my Dr. if that would be better. I appreciate the link, too.

DMS,

Re: #4 in that article. As a child we used DDT a lot around the house for ants and roaches, even after it was banned in the US. We were also exposed to a lot of auto exhaust, direct venting for hours at a time. In those days we had leaded gas. My sister and I have wondered if that had any effect on our memory problems.

Bev
Diagnosed 9/4/07
Sleep Study Titrated to 19 cm H2O
Rotating between Activa and Softgel
11/2/07 RemStar M Series Auto with AFlex 14-17
10/17/08 BiPAP Auto SV 13/13-23, BPM Auto, AHI avg <1