Study finds Brain Chemical plays a roll in apnea in Mice

socknitster · Post by **socknitster** » Fri Oct 12, 2007 11:25 am

Interesting reference to a study on the potential causes of sleep apnea I found in the journal SLEEP.

http://www.journalsleep.org/ViewAbstrac ... ionid=3356

Jen

msheda · Post by **msheda** » Fri Oct 12, 2007 11:28 am

"We studied sleep and breathing (whole-body plethysmography) in mutant mice that lack monoamine oxidase A (MAOA) and have increased concentrations of monoamines, including 5-HT. "

EEEEEEEEEEEEEEEEKKKK!

(actualy, it is very interesting, but couldn't help but focus on the mutant mice thing)

Guest · Post by **Guest** » Fri Oct 12, 2007 11:41 am

So now I'm no longer a hypochondriac, it turns out I'm a Mutant Mouse? Is that like a Teenage Mutant Ninja Turtle, except warmer and fuzzier?

Sorry, lack of sleep and the brain just lies there on the floor making stupid comments... Sorta like the really annoying drunk who won't leave the party, and you find him lying in the middle of your living room floor babbling to no one...

LOK,
Babs

jskinner · Post by **jskinner** » Fri Oct 12, 2007 12:27 pm

Hmmm, I wonder if the wide use of SSRI's in susceptible individuals actually can cause sleep apnea!

Now wouldn't that be something...

msheda · Post by **msheda** » Fri Oct 12, 2007 1:05 pm

so, the widespread use of SRRI is another attempt by the medical communities to blow air up our noses as opposed to smoke up our...

Sergey45 · Post by **Sergey45** » Fri Oct 12, 2007 1:55 pm

Just curios how many of us on this forum have tried SSRI? 30%, 50%?

Snoredog · Post by **Snoredog** » Fri Oct 12, 2007 2:02 pm

what a mickey mouse study

msheda · Post by **msheda** » Fri Oct 12, 2007 4:26 pm

Sergey45 wrote:Just curios how many of us on this forum have tried SSRI? 30%, 50%?

That question almost answers itself doesn't it? That you use the term SRRI and people know what your talking about without explaining it?

BTW... is Sleepy Carols avatar one of the Mutant Mice?

(that thing scares me when I'm tired... it like inflates it's face! )

allergyridden · Post by **allergyridden** » Fri Oct 12, 2007 4:54 pm

One interesting case is the association between violent criminal behavior and monoamine oxidase (MAO) activity in the brain. It has been known for many years that there is a statistical correlation between violence and the levels of MAO assayed in blood platelets. Lower MAO activity is found in violent criminals, both male and female. More recently, the underlying genetic defects have been characterized for a small number of extreme cases.

Heartful · Post by **Heartful** » Fri Oct 12, 2007 5:02 pm

They do tests on mutant mice?? I don't know what a mutant mice would be... but with the size of a mouse, the almost unexistant neck and probably very small lungs... what kind of sleep apnea can they induce??

That doesn't make much sense to me

Whatever medication that affects the deep stages of sleep surely do impact the sleep apnea. And SSRI's does great to mess up the brain chemistry so I wouldn't be surprised they find some correlation eventually.

A mutant mice... geez.. I have to google that!

That was an interesting article to share, Thanks Jen.

Heartful

echo · Post by **echo** » Fri Oct 12, 2007 5:44 pm

What is SSRI??

Heartful · Post by **Heartful** » Fri Oct 12, 2007 5:48 pm

Echo,

Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants used in the treatment of depression, anxiety disorders, and some personality disorders.

Heartful

Snoredog · Post by **Snoredog** » Fri Oct 12, 2007 6:00 pm

Heartful wrote:Echo,

Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants used in the treatment of depression, anxiety disorders, and some personality disorders.

Heartful

yep and they absolutely kill or slow down your metabolism:

http://health.msn.com/dietfitness/artic ... =100164851

echo · Post by **echo** » Fri Oct 12, 2007 6:05 pm

ahhhh. no thanks!

WxMan · Post by **WxMan** » Fri Oct 12, 2007 8:15 pm

Then we have this...an actual study on Homo Sapiens that came to the opposite conclusion. SSRIs may reduce apnea.

Here's the link:
http://www.annals-general-psychiatry.com/content/4/1/13

If you wish to "cut to the chase", scroll down to "Neurobiology of depression and upper airway control in OSA: the role of serotonin"

This one suggests that molecules increasing 5-HT neurotransmission actually improve the AHI.

Which leads to an obvious question for the board. Has anyone with the necessary software...and taking 5-HTP for sleep or other reasons, actually noticed a decrease in their AHI after beginning the "nutrient"? Or conversely, has their AHI increased after stopping it?

The study suggests that several compounds are under development that have the potential to reduce apnea.

Wouldn't it be nice to take a pill to control your apnea? Hope springs eternal. If that wish were to ever come to pass, we could start a new board "apneapilltalk.com"

Study finds Brain Chemical plays a roll in apnea in Mice

Study finds Brain Chemical plays a roll in apnea in Mice

DME'S should fear us now!

...jury is still out on this one

Mask