Sudden jump in AHI with new medication

[LSAT]

I guess we need to call him Dr. end-of-alphabet boy...

[puglover333]

Sleep position hasn't changed as far as I'm aware.

Increased the minimum pressure to 10 last night. Didn't make a difference.

I'll try 11 or 12 tonight.

[puglover333]

And I've been around long enough to know that xxyzx seems to get a kick out of riling people up and simply needs to be ignored.

[49er]

Sleep position hasn't changed as far as I'm aware.

Increased the minimum pressure to 10 last night. Didn't make a difference.

I'll try 11 or 12 tonight.

Good luck!

[nickdanger1]

And I've been around long enough to know that xxyzx seems to get a kick out of riling people up and simply needs to be ignored.

"Don't feed the troll" - Internet saying that points out that responding to troll comments (those meant to rile people up) gives the troll more attention and increases the troll's ability to troll (e.g. I suspect many of us wouldn't have even noticed the troll had posted if his comments hadn't been quoted in responses).

[MssDarla]

start medicine and AHI goes up
clearly that was the prime suspect in this crime drama

he is taking an antidepressant for pain
so wrong medicine to start with

Actually it is different kind of antidepressant , It works on the nerves which does help with pain, I was given it for fibro, I havent been taking it lately because I didn't think it helped but kinda glad now, I dont need more meds

[chunkyfrog]

Many drugs have undesirable side effects.
If it complicates another disorder, the first step would be to check with the doctor about a different drug or a lower dosage.
Sometimes we have to choose between two bad things.
For example, Oral prednisone screws with diabetes, but a topical ointment
may handle a rash of unknown origin, although a bit more slowly.

[puglover333]

Tried 10 and 12 without much success.
Not sure what to do.
Like I said, I'd really like to give the medicine a chance. I've tried so many other things.....

[aspen]

I can't use the ResMed EPR algorithm because it depends on a breath to trigger the increase of pressure after exhalation relief.

Sometimes I just don't. I'm having better luck with the Dream Station because the increase is based on time instead.

I called ResMed because otherwise I love their machine; the first machine they have that has a time option is the aircurve Vauto.

Not sure if this is your situation, but if it is, your machine may be unable to handle the medication side effects.

Tried 10 and 12 without much success.
Not sure what to do.
Like I said, I'd really like to give the medicine a chance. I've tried so many other things.....

[aspen]

I can't use the ResMed EPR algorithm because it depends on a breath to



if you dont then that is central apnea

if you have central apnea you need an ASV
ignore the libtard trolls who will say i am FOS

ASV is the only FDA approved treatment for central apnea

I'm aware. But I'm fighting a system that is uninterested in even rxing an
Apap. No way I would qualify and no way could I buy outright.

My gp has referred me to two other sleep labs, one neurological. Part of the problem is
I rouse for every event. Likely damage in a certain area of my brain. So if I only have five or
events, I wake up each time even with apap. Ahi low, sleep crappy.

So it's not just apnea I'm trying to solve.

[mangos21]

FYI you can also treat your pain topically. I'm a compounding pharmacist and regularly treat inflammatory and neuropathic pain for my patients with topical creams. The type of pain would dictate the number and type of ingredients.. ketamine, ketoprofen, amitriptyline, to name a few. you can avoid oral medication side effects this way and hopefully get your pain under control. PM me if you're interested in formulas.. I can recommend some.

Thanks

[aspen]

Well, it is the apnea. AHI was 60 (REM) and 29 (other stages) after first relapse. PLus medications (all CNS depressants) depress my breathing more than anything else. Even with that, CPAP therapy worked not too badly for a while. Then had the other thing happen .

So yeah. And since my neuro knows nothing about sleep, and my sleep specialist knows nothing about neurology ... caught in a major crack without help.

BTW pretty much all of the pain meds are off label uses of something designed for something else. Gaba and Lyrica are anti-seizure meds. Amitryptyline, nortriptyline, cymbalta are originally psych meds. (And the first two are very drying so I bet they would mess with CPAP therapy as well). And opiates .. well, people should run from them, especially those using CPAP. Really only NSAIDs and acetominophen are "just" pain meds.

I can't use the ResMed EPR algorithm because it depends on a breath to


if you dont then that is central apnea

if you have central apnea you need an ASV
ignore the libtard trolls who will say i am FOS

ASV is the only FDA approved treatment for central apnea

I'm aware. But I'm fighting a system that is uninterested in even rxing an
Apap. No way I would qualify and no way could I buy outright.

My gp has referred me to two other sleep labs, one neurological. Part of the problem is
I rouse for every event. Likely damage in a certain area of my brain. So if I only have five or
events, I wake up each time even with apap. Ahi low, sleep crappy.

So it's not just apnea I'm trying to solve.

==============

bureaucrats
cant live with them cant live without them

they prefer running very expensive sleep lab studies that have marginal value
but wont rent an actual device for a month that is cheaper and more meaningful to see the results

sounds like your real problem is not the apnea
fixing two issues at once is hard as doctors only want to treat their one problem

[WickedLoki]

xxyzx said:

googling for cymbalta/duloxetine the first side effects that pop up included difficulty breathing

so clearly , in spite of LSAT's incredulity, the medicine IS THE CAUSE OF THE APNEA problems now

I have looked on 4 different websites based on googling duloxetine. There are many things listed as side effects including drowsiness. THERE IS NO MENTION AF ANY SLEEP PROBLEMS. So clearly you are wrong AGAIN.

[zoocrewphoto]

Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).

Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

Side Effects
Nausea, dry mouth, constipation, loss of appetite, tiredness, drowsiness, or increased sweating may occur. If any of these effects persist or worsen, tell your doctor promptly.

Dizziness or lightheadedness may occur, especially when you first start or increase your dose of this drug. To reduce the risk of dizziness, lightheadedness, or falling, get up slowly when rising from a sitting or lying position.
**************************************************************************************
According to Web MD, Cymbalta *IS* prescribed for pain. And breathing issues are *NOT* listed in the side effect section. I suspect you read that in the typical allergic reaction section a breathing problem can be a sign of an allergic reaction to ANYTHING.

My mom also takes this medication for pain. She is diabetic and has peripheral neuropathy as well as fibromyalgia. She has had sleep apnea for at least 25 years, and her sleep apnea is well treated with a Resmed S9 autoset with a pressure range of 10-15. I check her data every few months, so if her medications affect her treatment, we would notice it and adjust her settings.

[zoocrewphoto]

Common Side Effects of Cymbalta (Duloxetine Hcl) Drug Center - RxList
http://www.rxlist.com/cymbalta-side-eff ... center.htm
Mar 14, 2017 - Cymbalta (duloxetine) is a selective serotonin and norepinephrine reuptake ... difficulty breathing; swelling of your face, lips, tongue, or throat.

As I already stated, that quote is from the section on allergic reaction which is to ANY Medication.

"Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat."

Will you have Difficulty in breathing with Cymbalta? - eHealthMe
http://www.ehealthme.com/ds/cymbalta/di ... breathing/
Difficulty in breathing is found among people who take Cymbalta, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also ...

According to the SAME website:

On Apr, 21, 2017

90,467 people reported to have side effects when taking Cymbalta.
Among them, 3,300 people (3.65%) have Difficulty in breathing

Less than 4% of people who have side effects have issues with breathing. This is NOT a common side effect.

The same website also has a list of common side effects at the top of the page. Breathing issues are NOT on that list.

Breathing Difficulties On Cymbalta - When Does It End? - What are ...
http://www.cymbaltawithdrawal.com › Cymbalta Withdrawal › What are you feeling?
Oct 18, 2013 - 21 posts - ‎9 authors
Hello, after being on Cymbalta for over a year, I tried to go off it in March, was hospitalized, and nearly died from difficulty breathing. I tried it ...

I could not find which actual post you were quoting. But this forum is about withdrawal, and sounds like the breathing problem was during the withdrawal process.

Cymbalta (Duloxetine hydrochloride) Drug / Medicine Information
http://www.news-medical.net/drugs/Cymbalta.aspx
Do not take CYMBALTA if you have an allergy to: ... Some of the symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin.

Again, referring to allergic reaction. Not a standard side effect of the medication. Anybody who is badly allergic to something can have a breathing reaction. It could be to peanuts, a dog, seafood, etc. Same list of possible reactions.
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