OT: No R.E.M Sleep (help)

General Discussion on any topic relating to CPAP and/or Sleep Apnea.
Jim-Bob
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Re: OT: No R.E.M Sleep (help)

Post by Jim-Bob » Fri Jun 29, 2012 9:11 pm

"One idea that has received much media attention is that REM sleep has an important role to play in memory consolidation. However the evidence for this is poor...Millions of human have taken monoamine oxidase (MAO) inhibitors or tricyclic antidepressants, often for 10 to 20 years. These drugs profoundly depress, or in many cases completely eliminate, all detectable aspects of REM sleep. However, there is not a single report of memory deficits attributable to such treatments. Likewise, well-studied individuals with permanent loss of REM sleep resulting from pontine damage show normal learning abilities; the best-studied such individual completed law school after his injury and was last reported to be the puzzle editor of his city newspaper." p. 107, "Principles and Practice of Sleep Medicine, 5th Edition" (2011), Kryger, Roth, and Dement. This from Chapter 8, "REM Sleep"

This from the pre-eminent text on sleep medicine. There's lots more there, and I recommend this text unreservedly.

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Re: OT: No R.E.M Sleep (help)

Post by lazer » Fri Jun 29, 2012 9:36 pm

When we switch into REM sleep, our breathing becomes more rapid, irregular, and shallow, our eyes jerk rapidly in various directions, and our limb muscles become temporarily paralyzed. Our heart rate increases, our blood pressure rises, and males develop penile erections.
http://www.ninds.nih.gov/disorders/brai ... _sleep.htm

That's enough to sell me.....

But seriously, some good reading at that link.

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BlackSpinner
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Re: OT: No R.E.M Sleep (help)

Post by BlackSpinner » Sat Jun 30, 2012 9:38 am

And this contradicts the fact that REM is not required for learning

http://serendip.brynmawr.edu/bb/neuro/n ... ppman.html
Learning tasks that need high levels of concentration or the acquisition of new skills is followed by an increase in REM sleep. (1) Many studies show that learning after having reached a plateau can only take place with the help of REM sleep. A study at MIT has shown that volunteers' skill at key-tapping and speed-spotting tasks improved by 20 per cent after one night's sleep after training, and with more extra nights, it increased even more. (4) Karni and Sagi's establishing that changes in the plasticity of particular neuronal loci which underlie perceptual learning may happen during sleep, also argues for the importance of sleep to memory. (7) The increased production of proteins, which also occurs during deep sleep, may be tied to the learning process if those proteins are in fact associated with learning. (6) Finally, backing up the idea that suppression of REM affects memory consolidation is the study by Dinges and Kribbs that shows that REM deprivation impaired performance on longer tasks, while shorter tasks remained unimpaired. (5)
http://serendip.brynmawr.edu/exchange/node/1776
Experiments on humans found that REM sleep deprivation leads to poor performance on a variety of recall tests or logical tasks. It has also been found that memory loss occurs when sleep is deprived on the same night or two nights after material has been learned. Interestingly, memory has been affected only when subjects have been selectively deprived of one of the first two or last two REM episodes of the night. In addition, REM density, or the number of REM's per minute, increases for several nights after complex material has been studied (7)
http://www.sciencedaily.com/releases/20 ... 111456.htm
Although the quiet rest and non-REM sleep groups received the same words prior to the association task, they displayed no improvement on the Remote Associates Test. However, the REM sleep group improved by almost 40 percent over their morning performances. The authors hypothesize that the formation of associative networks from previously unassociated information in the brain, leading to creative problem-solving, is facilitated by changes to neurotransmitter systems during REM sleep.

So basically you have nothing to worry about if you are a couch potato. But for the rest of us who want to do intelligent things - get REM sleep.
And if you don't get REM sleep and you can't understand the above papers and links, I totally understand.

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Jim-Bob
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Re: OT: No R.E.M Sleep (help)

Post by Jim-Bob » Sat Jun 30, 2012 10:50 am

BlackSpinner wrote:And this contradicts the fact that REM is not required for learning

http://serendip.brynmawr.edu/bb/neuro/n ... ppman.html
Learning tasks that need high levels of concentration or the acquisition of new skills is followed by an increase in REM sleep. (1) Many studies show that learning after having reached a plateau can only take place with the help of REM sleep. A study at MIT has shown that volunteers' skill at key-tapping and speed-spotting tasks improved by 20 per cent after one night's sleep after training, and with more extra nights, it increased even more. (4) Karni and Sagi's establishing that changes in the plasticity of particular neuronal loci which underlie perceptual learning may happen during sleep, also argues for the importance of sleep to memory. (7) The increased production of proteins, which also occurs during deep sleep, may be tied to the learning process if those proteins are in fact associated with learning. (6) Finally, backing up the idea that suppression of REM affects memory consolidation is the study by Dinges and Kribbs that shows that REM deprivation impaired performance on longer tasks, while shorter tasks remained unimpaired. (5)
http://serendip.brynmawr.edu/exchange/node/1776
Experiments on humans found that REM sleep deprivation leads to poor performance on a variety of recall tests or logical tasks. It has also been found that memory loss occurs when sleep is deprived on the same night or two nights after material has been learned. Interestingly, memory has been affected only when subjects have been selectively deprived of one of the first two or last two REM episodes of the night. In addition, REM density, or the number of REM's per minute, increases for several nights after complex material has been studied (7)
http://www.sciencedaily.com/releases/20 ... 111456.htm
Although the quiet rest and non-REM sleep groups received the same words prior to the association task, they displayed no improvement on the Remote Associates Test. However, the REM sleep group improved by almost 40 percent over their morning performances. The authors hypothesize that the formation of associative networks from previously unassociated information in the brain, leading to creative problem-solving, is facilitated by changes to neurotransmitter systems during REM sleep.

So basically you have nothing to worry about if you are a couch potato. But for the rest of us who want to do intelligent things - get REM sleep.
And if you don't get REM sleep and you can't understand the above papers and links, I totally understand.

Unbelievable! You cite the papers of students in a sophomore biology class from 10 years ago. At the top of the top two it even says:

"This paper reflects the research and thoughts of a student at the time the paper was written for a course at Bryn Mawr College. Like other materials on Serendip, it is not intended to be "authoritative" but rather to help others further develop their own explorations. Web links were active as of the time the paper was posted but are not updated."

You scour the web for something--anything--that looks like it supports your opinion. And the balance of evidence that doesn't go your way obtains virtually no purchase whatsoever on your mind. I don't know what it is that produces such rigidity, but it's almost certainly not REM sleep.

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BlackSpinner
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Re: OT: No R.E.M Sleep (help)

Post by BlackSpinner » Sat Jun 30, 2012 5:57 pm

I gather you can't really read either. I give up on you. Lack of REM sleep has obviously damaged you totally.

This is not a highschool student paper. There are plenty of links in it. Much research is done by grad students under the auspices of professors.
The last reference was 2010 article.
As for scouring - it was one Google search. Didn't take much effort to find the information anyone with 2 brain cells to rub together could have done it, even you.

And stop with the idiot screaming, I assume you are not 12 years old.

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Re: OT: No R.E.M Sleep (help)

Post by Jim-Bob » Sat Jun 30, 2012 8:30 pm

BlackSpinner wrote:I gather you can't really read either. I give up on you. Lack of REM sleep has obviously damaged you totally.

This is not a highschool student paper. There are plenty of links in it. Much research is done by grad students under the auspices of professors.
The last reference was 2010 article.
As for scouring - it was one Google search. Didn't take much effort to find the information anyone with 2 brain cells to rub together could have done it, even you.

And stop with the idiot screaming, I assume you are not 12 years old.
Who said high school? College sophomore obviously. It's "Biology 202", hence a lower-division college course. Do you think a grad student is taking "Biology 202"? It's just one non sequitur after another in your posts. That and empty bravado. Yes, I gather we have both had our say. I apologize for getting testy earlier.

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pats
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Re: OT: No R.E.M Sleep (help)

Post by pats » Sat Jun 30, 2012 11:45 pm

Jim-Bob wrote:Who said high school? College sophomore obviously. It's "Biology 202", hence a lower-division college course. Do you think a grad student is taking "Biology 202"? It's just one non sequitur after another in your posts. That and empty bravado. Yes, I gather we have both had our say. I apologize for getting testy earlier.
All the graduate courses I took at UCSD had numbers beginning with 2. The undergraduate course numbers started with 1. Therefore it is at least possible that a grad student would be taking a course called "Biology 202".

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Jim-Bob
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Re: OT: No R.E.M Sleep (help)

Post by Jim-Bob » Sun Jul 01, 2012 12:08 am

pats wrote:
Jim-Bob wrote:Who said high school? College sophomore obviously. It's "Biology 202", hence a lower-division college course. Do you think a grad student is taking "Biology 202"? It's just one non sequitur after another in your posts. That and empty bravado. Yes, I gather we have both had our say. I apologize for getting testy earlier.
All the graduate courses I took at UCSD had numbers beginning with 2. The undergraduate course numbers started with 1. Therefore it is at least possible that a grad student would be taking a course called "Biology 202".
Just have a look at the links up above. You'll see what it is. Bryn Mawr College, http://www.brynmawr.edu/biology/ Undergraduate.

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Re: OT: No R.E.M Sleep (help)

Post by 49er » Sun Jul 01, 2012 6:12 am

I have nothing to support what I am about to say since Antidepressant withdrawal is not studied in the medical community. It is not easy to understand why which I won't get into.

Anyway, the Rem suppression you speak of with ADs worked so well that withdrawal insomnia is one of the most common complaints on AD withdrawal boards. Yes, I am being sarcastic.

And ADs don't work well for most people long term and leave horrific side effects.

Anyway, I can't prove this but I wouldn't be surprised if my long term use of 4 psych meds that I finally rid myself of in 2010 has contributed to my difficulties in adjusting to cpap treatment.

Personally, I agree with Black Spinner.

49er



Jim-Bob wrote:
BlackSpinner wrote:
Jim-Bob wrote: 1. R.E.M. sleep is not something you need. It is not restorative sleep. And what happened in a sleep study and what happens at home are two different things.
Lack of REM sleep causes failure of memory, lack of ability to learn new things and various kind of psychoses. But otherwise it is not needed.

Please support this. Some antidepressants virtually extinguish REM in folks who were having normal amounts of it before treatment. In fact, REM suppression in itself is a treatment for depression. Psychoses??? What have you been smoking? REM is likely more important the younger you are, and perhaps especially for fetuses.

The wild opinions seem to be flying fast and furious in this thread and perhaps it's best to bring some documentation to the table. I'll check in with mine tonight.

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Re: OT: No R.E.M Sleep (help)

Post by BlackSpinner » Sun Jul 01, 2012 9:22 am

[quote="Jim-Bob"

Just have a look at the links up above. You'll see what it is. Bryn Mawr College, http://www.brynmawr.edu/biology/ Undergraduate.[/quote]

The whole discussion is irrelevant anyway since the other links, which are not student papers, say the same thing. This is called a "Straw man argument " which means it is just a red herring.

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Re: OT: No R.E.M Sleep (help)

Post by chunkyfrog » Sun Jul 01, 2012 11:25 am

This thread began with an inquiry about the usefulness of a Zeo in helping improve one's quality of sleep,
and a request for advice on interpretation of the data.
It has since progressed into an interesting debate about the relative value of REM sleep in adults.
I think we can agree that the jury may still be out, due to conflicting opinions cited.
We might want to conclude for the OP that the 'lack of REM' indicated may or my not be a
result of abnormal conditions and short time elapsed in the lab; and that depending on
other conditions not available here, may or may not be significant.
To the O.P.: It probably wouldn't hurt to get a Zeo; you may find that you do indeed have some REM,
and it may be consistent with your age and general condition.

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