POLL: Do You Have a Narrow or Wide Xpap Pressure Range (ed)

MY 30 day 90% average is 9.5

My autopap is set for a range of 5-20



now I know what an x pap is, thanks!

elena

What a stupid poll!



Just kidding. Nicely done poll, as is usual with your posts, Mars.

I am running autobilevel with a fixed distance between IPAP and EPAP of 4 cm. My minimum EPAP is 9 and my maximum IPAP is 16.

So my question is (and you knew I had one, right? ) Should I choose 7 or 3 in the poll? The range of experienced pressures is 7 but the range of automatic movement is only 3, since the pressure support takes up 4 cm of that 7.

My guess would be that I should choose 3. My reasoning is that a ResMed-APAP user with EPR (exhale pressure relief) on 3 would not add 3 to his selected range in the poll, even though that increases the range of pressures experienced, so why would an autobilevel user count PS (pressure support), since that is virtually the same thing, right?

So, do I have your permission to choose "3" in the poll? Or have I just confused everyone, including myself? Or was I not listening and the answer is somewhere in those links? Or is my whiny bellyaching about my confusion something I should be embarrassed about, since it gives too much of a window into my tormented existence in a world where there aren't always easy answers? Or is my asking all these questions particularly irritating to you and the board as a whole? And should I now arrange for my own poll to ask the entire board whether I should choose "7" or "3" in your poll?

I'm exhausted.

I love polls!

jeff

yeah i was actually wondering why there's wasn't a separate option to indicate bipap, since the 'spread' there is different from the 'apap range'. i was waiting to see who would flag this first!

leave it jeff to put it so eloquently!

in this new hypothetical poll i will vote for : JNK and his tormented soul

p.s. I would have also have voted for "3" in your case jnk...

jnk wrote:
I am running autobilevel with a fixed distance between IPAP and EPAP of 4 cm. My minimum EPAP is 9 and my maximum IPAP is 16.

So my question is (and you knew I had one, right? ) Should I choose 7 or 3 in the poll? The range of experienced pressures is 7 but the range of automatic movement is only 3, since the pressure support takes up 4 cm of that 7.


jeff

Hi Jeff

As I explained to your receptionist several regulators of endocytic trafficking have recently been identified as tumour suppressors in Drosophila. These include components of the endosomal sorting complex required for transport (ESCRT) machinery. Disruption of subunits of ESCRT-I and –II leads to cell-autonomous endosomal accumulation of ubiquitinated receptors, loss of apicobasal polarity and epithelial integrity, and increased cell death. That means that the disruption of the ATPase dVps4, the most downstream component of the ESCRT machinery, causes the same array of cellular phenotypes. In your case it was found that loss of epithelial integrity and increased apoptosis, but not loss of cell polarity, require the activation of JNK signalling. Abrogation of JNK signalling prevents apoptosis in dVps4 deficient cells. Indeed double deficiency in dVps4 and JNK signalling leads to the formation of neoplastic tumours. Which means that your dvps4 is a tumour suppressor in Drosophila and that JNK is central to the cell-autonomous phenotypes of ESCRT-deficient cells.

But as none of the above applies to you anyway, I should just ignore it.

So there you have it. Your answer in a nutshell.

I knew I should have waited until you were free.

cheers

Mars

Cool! So "3" it is. Thanks, Mars!



But in the spirit of . . .

Copyright: © 2009 Rodahl et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

I would just like to say . . .

Rodahl LM, Haglund K, Sem-Jacobsen C, Wendler F, Vincent J-P, et al. (2009) Disruption of Vps4 and JNK Function in Drosophila Causes Tumour Growth. PLoS ONE 4(2): e4354. doi:10.1371/journal.pone.0004354

I wouldn't want a boatload of Norwegians to come looking for us for stealing their, uh, thunder. Those shiny hats with the bull horns always scare me.

And always remember that . . .

"A variety of stress stimuli can activate JNK. . . . Specific phosphatases normally inhibit the activity of JNK itself and the activity of proteins linked to JNK activation."--http://en.wikipedia.org/wiki/JNK

Hi Jeff

Well, I guess I deserved to be shown up as the dilettante plagiarist that I am.

Trouble is I am writing these posts when I should be in bed sleeping. The fact is my compulsive nature did not leave me just because I stopped drinking, nor did I suddenly get sane when I started cpap treatment.

So I will rest my weary head with the thought that never again will I try to be a smart-ass with JNK.

So until the next time.

cheers

Mars

PS I just deleted a post that really needed a song of yours, but thought it was not my place to link to it

mars wrote:Hi Jeff

Well, I guess I deserved to be shown up as the dilettante plagiarist that I am.

Trouble is I am writing these posts when I should be in bed sleeping. The fact is my compulsive nature did not leave me just because I stopped drinking, nor did I suddenly get sane when I started cpap treatment.

So I will rest my weary head with the thought that never again will I try to be a smart-arse with JNK.

So until the next time.

cheers

Mars

PS I just deleted a post that really needed a song of yours, but thought it was not my place to link to it

Hey look, you, I'm the smart aleck here, not you!

Show you up? Nope. Just trying to join in your fun, since I found your post about JNK to be absolutely hilarious.

Sleeping is important.

"Compulsive" is how most of us make a living. It is OK to be compulsive as long as it is compelling, right?

Sanity is highly overrated.

I liked the post you deleted. The Mars/Thor joke was great.

And you can feel free to quote one of my songs any time. Some days I hate my songs; other times I think they are brilliant. (I think there is a diagnosis for that.) I am a very hard guy to offend, Mars, and I always find your posts interesting, educational, and entertaining, whether we are both having a good day or not.

I chose "3" for the poll, then was disappointed that I was in the majority. How can I change my answer to "7"?

jeff

I'm 3-4.

Currently set to 7.8 - 12 cm. My titration was 7cm.

With both my S8 and S9 autosets i find that leaving the bottom pressure setting too low means that the machine prefers to use a lower pressure than 7 and i get more events.

Cheers
UB

jnk wrote:I liked the post you deleted. The Mars/Thor joke was great.

I saw the post that Mars deleted. I didn't realize that the Mars/Thor statement was a joke.

And you can feel free to quote one of my songs any time. Some days I hate my songs; other times I think they are brilliant.

Jeff, I've been meaning to tell you how much I enjoy your music. You are a brilliant songwriter and a very talented musician/singer! Thanks for sharing your gifts with the world.

DreamOn wrote: . . . I didn't realize that the Mars/Thor statement was a joke.

I knew Mars had friends in high places, but if he's met Thor, I'd REALLY better start treating him better!

DreamOn wrote:Thanks for sharing your gifts with the world.

Thanks for that, DreamOn. Hobbies keep us relatively sane, overrated though sanity is.

And Uncle Bob was trying SO hard to get this thread back on topic.

jeff

mars wrote:...

Good one, Mars! JNK enjoying your fame in fruit fly genetics?

Mars said - Well, I guess I deserved to be shown up as the dilettante plagiarist that I am.
So I will rest my weary head with the thought that never again will I try to be a smart-ass with JNK.
So until the next time.

I couldn't find a smiley for tongue-in-cheek, so I guess I should have used But then again, it all might be true. By the way, JNK, that was a great post you did in reply.

JNK said - I knew Mars had friends in high places, but if he's met Thor, I'd REALLY better start treating him better!

You got that right!

I used to work in Oslo, so Thor and I have been buddies for a long time. But don't worry, the Vikings are going nowhere.

http://www.norwayguide.no/ta/viking-oslo.htm

Muse-Inc said - Good one, Mars! JNK enjoying your fame in fruit fly genetics?

Thanks for the compliment, always glad to help the progress of science.

http://www.guardian.co.uk/science/2001/ ... echnology2

http://www.physorg.com/news155751263.html

JNK said - And you can feel free to quote one of my songs any time.

The original thread is at -

viewtopic.php?f=1&t=48634&st=0&sk=t&sd= ... k&start=15

one of my all-time favourite threads.

And as I have always dreamed of being a DJ, I hereby present to everybody my favourite JNK masterpiece -

The lyrics -
http://www.jamendo.com/en/track/513397

and the man himself
http://www.jamendo.com/en/?m=player&url ... F60064%2F1

Looking at the Generation Thread has made me all nostalgic, so here is what (part) my young teenage years were about -

British skiffe
https://www.youtube.com/watch?v=EEblivwPrpU
https://www.youtube.com/watch?v=fKotu3lrjKA

which was the start of British Rock n Roll
https://www.youtube.com/watch?v=r4IA7DR ... 1&index=18

and here was my introduction to R & B (the real R & B) (I saw them LIVE in Manchester).
https://www.youtube.com/watch?v=q4jCsq2aFe0

I could go on forever, but, hey, isn't this a cpap forum. Better get back on track.

Uncle Bob said -I'm 3-4. Currently set to 7.8 - 12 cm. My titration was 7cm.
With both my S8 and S9 autosets i find that leaving the bottom pressure setting too low means that the machine prefers to use a lower pressure than 7 and i get more events.
Cheers UB

JNK said - And Uncle Bob was trying SO hard to get this thread back on topic.

Uncle Bob, thanks for that heroic attempt to get the thread back on track. I reckon you deserve the "Cpaptalk Stay Focussed Award"

The results of the poll so far are really interesting. In fact, it has encouraged me to start experimenting with a wider range of cmH2O pressure. Lets see what happens

If you have not yet polled, please consider doing so. The more of us that do, the more accurate the results.

cheers

Mars

mars, apparently you suffer from Expressive Sarcasm Disorder (ESD) and thus might benefit from the use of the SarcMarc (TM)(R)(C)
http://www.telegraph.co.uk/technology/n ... usion.html

echo wrote:mars, apparently you suffer from Expressive Sarcasm Disorder (ESD) and thus might benefit from the use of the SarcMarc (TM)(R)(C)
http://www.telegraph.co.uk/technology/n ... usion.html

I don't get it.