Medications and thier Effect on Sleep Architecture

Here is a great list of a series of medications that effect sleep architecture.

Enjoy.. T

Drug Class: Benzodiazepine

Alprazolam (Xanax)
Chlordiazepoxide (Librium)
Clonazepam (Klonopin)
Clorazepate(Tranxene)
Diazepam (Valium)
Estazolam (ProSom)
Flurazepam (Dalmane)
Halazepam (Paxipam)
Lorazepam (Ativan)
Midazolam (Versed)
Oxazepam (Serax)
Quazepam (Doral)
Temazepam (Restoril)
Triazolam (Halcion)
Effects on sleep: Supresses SWS, supresses REM, decreased stage 1, increased stage 2, decreased myclonus, increased apneas, shortened sleep latency.

Drug Class: MAO Inhibitors

Isocarboxazid (Marplan)
Phenelzine (Nardil)
Tranylcypromine (Parnate)
Effects on sleep: Supresses REM

Drug Class: Miscellaneous

Buspirone (BuSpar) Causes/exacerbates insomnia
Nefazodone (Serzone) Dunno
Trazodone (Desyrel) I know, but can't remember

Drug Class: Sedating Hypnotics/Hynotics

Chloral Hydrate (Noctec, Aquachloral)
Diphenhydramine (Benadryl, Bena-D, Bena-hyst, Benoject, Dihydrex, Diphenacen, Genahist, Hydramine, Hydramyn, Hydrexin, Nordryl, Tusstat, Wehdryl, OTC-Benadryl, Excedrin PM, Extra-Strength Tylenol PM, Sominex Pain Relief, Unisom with Pain Relief)
Glutethimide (Doriden)
Meprobamate (Equanil)
Paraldehyde (Paral)
Zaleplon (Sonata)
Zolpidem (Ambien)
Zopiclone (Imovane-not available in the U.S.)
Effects on sleep: Supresses SWS, Increases SWS (weird, huh?) decresed myclonus, sleep disturbances

Drug Class: Stimulants

Amphetamine
Amphetamine/Dextroamphetamine (Adderall)
Dextroamphetamine (Dexedrine)
Laevoamphetamine (Benzedrine)
Modafinil (Provigil)
Methamphetamine (Desoxyn, Methedrine)
Methylphenidate (Ritalin, Ritalin-SR)
Pemoline (Cylert)
Effects on sleep: Supresses, REM, REM delay

Drug Class: Tricyclics

Amitriptyline (Elavil, Endep)
Amoxapine (Asendin)
Clomipramine (Anafranil)
Desipramine (Norpramin, Pertofrane)
Dothiepin (Prothiaden)
Doxepin (Sinequan, Adapin)
Imipramine (Tofranil, Janimine)
Lofepramine (Gamanil)
Maprotiline (Ludiomil)
Mirtazapine (Remeron)
Nortriptyline (Aventyl, Pamelor)
Protriptyline (Vivactil)
Trimipramine (Surmontil)
Effects on sleep: Supresses REM, increases SWS, drowsiness, somnambulism, sedating effects

Drug Class: Amino-Ketone Derivative

Bupropion (Wellbutrin, Zyban)
Venlafaxine (Effexor)
Effects on sleep: causes/exacerbates insomnia

Drug Class: SSRIs

Citalopram (Celexa)
Paroxetine (Paxil)
Fluoxetine (Prozac)
Sertraline (Zoloft)
Fluvoxamine (Luvox)
Effects on sleep: Supresses SWS, supresses REM, REM delay, increased SREM, causes/exacerbates insomnia

Ted,

Thanks for the great reference material. While you're at it could you define the sleep architecture terms you've used SWS, stage 1, etc...

Thanks!

Hi Titrator

Thanks for the list......Some of those meds are used for anti depressants some of those meds I heard of. I know a few people who use the meds listed on your list.

I heard of Celexa or better known Citropram. That treats depressive illnesses. I found that some as a side effect make people sleep heavier then usual.

Like the one listed on Benzos are sleeping meds.....ie: Tamaze

Madopar is a anti parkingson's med....controls restless leg sydrome.

I consider, that you commit an error. I suggest it to discuss.