Upper Airway Anatomy and Sleep Apena

ChicagoGranny wrote: ↑

Fri Dec 13, 2019 12:17 pm

KandyX wrote: ↑

Fri Dec 13, 2019 6:42 am

Yea, Dymista is one of the best nasal sprays. I use it for nonallergic rhinitis.

You are using the wrong product. Dymista is a combination of azelastine hydrochloride and fluticasone propionate. Azelastine hydrochloride treats allergic rhinitis. Since you need something for nonallergic rhinitis, it would be better to use a single active ingredient product like fluticasone propionate. There is no use to treat with a drug you don't need and possibly have undesired side effects.

Why do you think that?
https://www.mayoclinic.org/diseases-con ... c-20351235

While oral antihistamines don't seem to help nonallergic rhinitis, nasal sprays containing an antihistamine may reduce symptoms of nonallergic rhinitis.

https://www.tandfonline.com/doi/full/10.1586/eci.09.38

Azelastine nasal spray is a second-generation antihistamine, indicated for the treatment of allergic and nonallergic rhinitis in both adults and children.

https://waojournal.biomedcentral.com/ar ... 318196ca1e

Although azelastine is primarily an antihistamine, it is unlikely that its efficacy in VMR is due to histamine receptor blockade. Instead, it is probably azelastine's actions as an anti-inflammatory and neuroinflammatory blocker that makes this medication useful in treating VMR or NAR. Azelastine has been shown to deplete inflammatory neuropeptides in the nasal mucosa; to reduce levels of proinflammatory cytokines, leukotrienes, and cell adhesion molecules; and to inhibit mast cell degranulation.

Geer1 wrote: ↑

Sat Dec 14, 2019 8:47 am

Geer1

KandyX wrote: ↑

Sat Dec 14, 2019 9:09 am

KandyX

OK, the evidence you presented convinced me.

Sorry, I caused you to waste part of your Saturday morning digging through google.

I have found that if I can get my sinuses open with saline, corticosteroids, capsaicin, or whatever (NOT Afrin or any similar meds), CPAP with a pillow mask will help keep them open. Pillows work better than nasal or full face because of the pressure differential between the inside and outside of the nostrils. Beyond that, the pressure seems to work like a compression sock for my turbinates. A low dose of Mucinex (NOT Mucinex D) also helps. It only works if the air can get through though. The pressure is not even remotely high enough to force the passages open, but if some air can get through, it shrinks the turbinates and I wake up breathing well in the morning.

OTOH, a full face mask like the F20 clogs me up within minutes and forces me to breathe through my mouth.

ragtopcircus wrote: ↑

Mon Dec 16, 2019 9:23 am

capsaicin

I really like a capsaicin spray - works instantly and so convenient. Is regular use a potential problem? It has never been tested for short-term use, let alone long-term use. I use it infrequently for fear regular use might eventually do permanent damage to the mucous membrane. ???

ragtopcircus wrote: ↑

Mon Dec 16, 2019 9:23 am

. . .
but if some air can get through, it shrinks the turbinates and I wake up breathing well in the morning.
. . .

This happens to me as well.
It seems that a little flow helps cool and reduce swelling--and fairly quickly, too.

I don't get congestion when I'm up an about but when I lay down my nose gets congested to where I can hardly breath through it. I use a nasal cushion or nasal pillows. I fire up the cpap and probably within a minute the passages open up. I wish it was that simple for everyone.