OSA and liver disease

General Discussion on any topic relating to CPAP and/or Sleep Apnea.
seekingwellness2016
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OSA and liver disease

Post by seekingwellness2016 » Mon Sep 05, 2016 5:14 pm

In looking back through some records I see that my liver enzymes have periodically been elevated over the years, with the most recent (2014) showing ALT 50% above the upper limit of normal and AST at the upper limit. Labs otherwise pretty normal. I note some literature suggesting that non-alcoholic fatty liver disease may be associated with OSA. I consume very little alcohol. Has anyone required further evaluation of possible liver abnormalities?

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chunkyfrog
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Re: OSA and liver disease

Post by chunkyfrog » Mon Sep 05, 2016 5:19 pm

Losing weight generally helps lower those levels, but only while excess weight is kept off.
No direct connection with cpap, to my knowledge.

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Julie
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Re: OSA and liver disease

Post by Julie » Mon Sep 05, 2016 5:50 pm

Never heard of it connected to OSA, but I suppose if your general health has been affected over a long time, it could incidentally have deteriorated along with other organs.

seekingwellness2016
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Re: OSA and liver disease

Post by seekingwellness2016 » Mon Sep 05, 2016 6:03 pm

Here is just one commentary in the NY Times last year, describing a couple of studies that indicate a link:

http://well.blogs.nytimes.com/2015/02/2 ... a-related/

I am not overweight (BMI ~21), may be one reason why apnea was not considered in my case, unfortunately. But seems that intermittent hypoxia alone could damage the liver and lead to these changes.

D.H.
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Re: OSA and liver disease

Post by D.H. » Mon Sep 05, 2016 6:07 pm

Wow!

It was observed that I had a "fatty liver" prior to CPAP use and did not within a year of starting CPAP. The doctor at the time (many years ago) said that there was no known connection. However, I always suspected this since this is when the problem went away.

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ckeith
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Re: OSA and liver disease

Post by ckeith » Mon Sep 05, 2016 7:58 pm

I'm NEW here - and fain to give advice
But my doctor told me that my Apnea causes my Blood Oxygen Level to drop dangerously low
When this happens ALL Organs suffer and can eventually be damaged -

https://en.wikipedia.org/wiki/Oxygen_sa ... (medicine)

.

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Janknitz
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Re: OSA and liver disease

Post by Janknitz » Tue Sep 06, 2016 5:12 pm

NAFLD is most likely a result of excess carbohydrate intake and insulin resistance. People who go on low carb/keto dies regularly see significant reversal of NAFLD.

Sleep apnea messes with your metabolism, interferes with hormones and increases stress and inflammation. So treating sleep apnea will likely help, too.

On a keto FB group I'm on, someone posted today that within 17 days of going keto, his wife, who has a genetic abnormality known as "Alpha 1-Antitrypsin Deficiency" in which her liver creates enzymes that attack her lungs and causes COPD, was able to go 5 days in a row without supplemental oxygen for the first time in YEARS. Pretty amazing in such a short time.
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