ASV Part 3 - My Rocky Road from CPAP to ASV Therapy

General Discussion on any topic relating to CPAP and/or Sleep Apnea.
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Grand-PAP
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ASV Part 3 - My Rocky Road from CPAP to ASV Therapy

Post by Grand-PAP » Sun May 06, 2012 12:25 pm

Grand-PAP wrote:This is instalment THREE of my Rocky Road. It's a little long, so feel free to take a detour!

1st Post: viewtopic.php?f=1&t=75762&p=692914&hili ... d+#p692914

2nd Post: viewtopic.php?f=1&t=77531&p=706282#p706282

Importand Caveat: I am NOT suggesting than anyone read this and decide to venture into this degree of self-directed therapy.
In this post, I am going to stay as BASIC as possible. That works well for me, because I only have a basic understanding. Therefore, this post will probably have something for everyone. A "little" understanding for Newbies and a good laugh for the more experienced!

In the prior post, I indicated that I would provide information regarding pressure changes and compare and contract the S9 with the S1.

On the S9 VPAP my initial pressures were:
EPAP: 6
Min PS: 3
Max PS: 8
Over time I made three adjustments:
6, 3, 10
6, 4, 11
6, 4, 14
I have had those settings for a couple of weeks and they have virtually eliminated all events.
____________________________
On the S1 my Rx settings were:
Mode: AutoSV
Max Pressure: 25.0 cm H20
Max EPAP: 15 cm
Min EPAP: 8.0 cm
Max PS: 15 cm
Min PS: 4.0 cm

I kept the Doc’s Rx for the first three weeks, with only minor adjustments to the EPAPs. The minor adjustments worked well to reduce the OAs and CAs, but I still had large numbers of hypopneas and pressure pulses. At that point, I felt both the S9 and S1 were pretty much doing their jobs well, with the exception of the hypopneas and pressure pulses. Then on April 20th, I began the experiment below.
Pugsy often talks about the bi-level machines being “three machines in one” -- CPAP, APAP and Bi-Level.
Well, I would like to discuss a special “ASV” machine – A STRAIGHT CPAP MACHINE WITH ASV.

I began my therapy on a straight CPAP machine set at 10cm H2O.

As with most people, I experimented with EPR (Expiration Pressure Relief). It worked fine, but I quickly realized that I didn’t need the reduced pressure, because I had no problem exhaling against the 10cm. So, I turned the EPR off. A little over a month ago, I got a PR System One BiPAP autoSV Advanced Machine.

NOW: My first BASIC Primer:

Min IPAP = Current EPAP plus Min PS
Max IPAP = Current EPAP plus Max PS

Therefore: My IPAP could range between 12 cm and 25 cm:

12 (Min EPAP of 8 + Min PS of 4)
25 (Max EPAP of 15 and Max PS of 15) -- NOT 30 because Maximum Pressure is 25

If my last EPAP were 8 AND I DID NOT INHALE, the ASV would begin to increase pressure and pulse to cause me to take the breath. So, it could quickly change from 12 cm (Min EPAP + Min PS of 4) to 25 cm. Then when it was successful at dealing with the CA, it could rapidly drop back down to Min EPAP of 8. That didn’t bother me when I was asleep, but during the early evening, before going to sleep, with “normal” position movement and/or irregular breathing the machine would start the pressure pulsing process. The comedian, Jim Carey, had a routine where he used a bathroom plunger to “pump” his mouth. I often envisioned that when the PR was rapidly toggling up and down with pressure changes. It became very irritating.

On April 19th, I was on a phone conversation with another cpaptalk ASV member and we were discussing this issue. His experience on straight CPAP was similar to mine and he also did not have difficulty with CONSTANT inhale and exhale pressure. I mentioned to him that I had considered turning my autoSV into a "Straight CPAP with ASV", by raising my Min EPAP to my CPAP pressure of 10 cm and setting my Min PS to ZERO.

The THEORY was:

1. With “normal” breathing Min EPAP would be 10 and Min IPAP would be 10 –- a straight CPAP.
2. When the machine determined that I had not taken a breath, the ASV would kick in and move the IPAP from 10 to a max of 25, as needed.
3. It would shorten the pressure range increase by 2 cm (Min EPAP of 8 to Min EPAP of 10).
4. When returning after inhalation occurred, it would not have to drop as far – back to Min EPAP of 10 instead of 8.
5. Because of #3 and #4, the up and down pressure movement should be more comfortable.

Neither of us knew if it would work or not. He bit immediately and did the PS change that night. I didn’t do it until the next day. A couple of days later we compared notes and not only did it work, but both of us felt it was considerable more comfortable. I have had those setting since the experiment.

So, that was the experiment.

Now for some of the justification and results:

In the early stages of therapy I was making the “normal cpaptalk member” adjustments of EPAP Min and/or Max to address both Obstructive and Clear Airway Apneas. Those adjustments were successful, but not germane to this post. I had two issues that I was trying to address:

1. Extremely high hypopneas
2. Huge numbers of pressure pulses

Here's where my ignorance shines through, but I felt that if I could eliminate some of the pressure variations and reduce the range of pressures between EPAP and IPAP, that I might see improvement in both the Hypopneas and Pressure Pulses. Below I have pasted two graphs:

Consider this graph. This was before I ZEROed out the PS. My feeble analysis was that I had major pressure variations and a huge number of pressure pulses.

Image

Then, consider this graph where the only change was ZERO Min PS. It flattened the pressure variations and virtually eliminated the Pressure Pulses:

Image

OK, this is when you experts laugh! I don't know if I am dreaming or not, but it seems to work.

Finally consider this:
Image

The first 28 days, I had the Min PS at 5. For that 28 day period, I had a HI of 3.5 and an average of 90.3 Pressure Pulses per hour. For the 12 days after Zero Min PS, I had HI of 1.5 and 14.5 Pressure Pulses per hour.

Sometime I think we get caught up in dealing with Indexes and miss a bigger picture. Those two Pressure Pulses figures of 90.3 per hour and 16.7 per hour can be a little misleading. Forgetting "averages" for a minute, prior to reducing the Min PS to ZERO, the two highest nights Pressure Pulses were 2,835 and 1,131 per night. After the drop, the two lowest Pressure Pulses were 5 and 30. IMHO, that's good!

So, there you go experts -- feel free to weigh in and let me know if I am crazy or not -- but, be gentle; I am very sensitive!

Sleep well!
Last edited by Grand-PAP on Mon May 07, 2012 9:10 am, edited 3 times in total.

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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by Pugsy » Sun May 06, 2012 12:46 pm

So if I get this straight...you dummied down the ASV machine by removing PS and you got rid of the annoying pressure pulses and your AHI dropped and you feel better?
Sounds like a win win situation to me. Whatever works and lets you feel better is sure number one in my book. I think I could dummy down my VPAP auto to essentially make it an APAP but I haven't tried it. I kind of like the pressure support and kind of reluctant to part with it.

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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by -SWS » Sun May 06, 2012 12:47 pm

Image
Well, that makes good sense to me. Respironics defaults PS min to 0 for good reason. And that good reason is probably:

Bilevel Positive Airway Pressure Worsens Central Apneas During Sleep


In other words, SOME users find CPAP to be less detabilizing to their central respiration than BiLevel. When you set PS min to 5, you are running ordinary BiLevel as base modality---with ASV IPAP fluctuations kicking in as needed. However, when you set PS min to 0, you are running CPAP as your base modality---once again with ASV IPAP fluctations occasionally kicking in as-needed. Apparently you find CPAP base-modality less destabilizing than BiLevel base-modality. If you allow EPAP to automatically fluctuate, then you have introduced the same very gradual static-pressure fluctuations as ordinary APAP. That's the equivalent of gradually and automatically changing CPAP's static pressure. The quick IPAP fluctuations are the adaptive part of servo ventilation.

Anyway, your central drive apparently doesn't fare as well when BiLevel is constantly delivered on every breath; however, it benefits from adaptive IPAP stepping in during your moments of ventilatory undershoot. I'm glad to hear you are getting great results by fine-tuning your ASV settings!

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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by -SWS » Sun May 06, 2012 12:57 pm

Pugsy wrote:So if I get this straight...you dummied down the ASV machine by removing PS and you got rid of the annoying pressure pulses and your AHI dropped and you feel better?
Rather he set PS min to where Respironics prefers and factory-defaults that particular setting.

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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by Pugsy » Sun May 06, 2012 1:06 pm

-SWS wrote:Rather he set PS min to where Respironics prefers and factory-defaults that particular setting.
Ahh, didn't know that PS 0 was the default.
I am the first to admit that I don't know much about the inner workings of the ASV machines.
I barely have a good handle on how and why my machine does what it does and still no clue why it works for me.

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Grand-PAP
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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by Grand-PAP » Sun May 06, 2012 1:08 pm

-SWS wrote:Rather he set PS min to where Respironics prefers and factory-defaults that particular setting.
Hi -SWS,

Duh! That's good to know. The RT set the Rx pressures. I didn't know that the factory default was Min PS Zero.

Thanks!

-SWS
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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by -SWS » Sun May 06, 2012 1:14 pm

Grand-PAP, Pugsy- Now you two have me doubting. The Respironics ASV before Grand-PAP's "Advanced" model was defaulted to PS min of 0. And the titration protocol went along with that as well. I'll look for info about the new Advanced model, to see if they changed that default. If so, I'll report my boo-boo back to this thread...

Pugsy wrote:
-SWS wrote:Rather he set PS min to where Respironics prefers and factory-defaults that particular setting.
Ahh, didn't know that PS 0 was the default.
I am the first to admit that I don't know much about the inner workings of the ASV machines.
I barely have a good handle on how and why my machine does what it does and still no clue why it works for me.
Hey, I'm still scratching my head over the "BiLevel puzzle" you sent me via PM.



on edit: the ASV Advanced is still defaulted to PS min of 0. Suggested titration protocol: http://www.healthcare.philips.com/asset ... otocol.pdf

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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by Grand-PAP » Mon May 07, 2012 10:42 am

-SWS wrote:the ASV Advanced is still defaulted to PS min of 0
Hi -SWS,

Thanks for the followup. It's good info to have. Also, thanks for the . . .
Suggested titration protocol.

It really doesn't make sense to me that they would start ASV titration with Min EPAP of 4 and Min PS of 0!

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Re: ASV Part 3 - My Rock Road from CPAP to ASV Therapy

Post by -SWS » Mon May 07, 2012 11:45 am

Grand-PAP wrote: It really doesn't make sense to me that they would start ASV titration with Min EPAP of 4 and Min PS of 0!
Let's talk about the min PS of 0 first. There's a BiLevel study I linked to that clearly shows PS > 0 introduces problems in some patients. Why should a titration protocol start min PS at a level high enough that the protocol is guaranteed to introduce iatrogenc problems in a subset of patients? In light of your own improved results with Min PS of 0, why do you think it would be preferable to start PS Min high enough to have skipped your optimal Min PS setting?

Similarly the protocol's beginning Min EPAP starts at a level low enough to avoid introducing iatrogenic central instability in a subset of patients. Some patients destabilize at CPAP pressures of 5cm. Those patients are going to fare better with EPAP sitting just as low as possible when there is no intermittent obstruction to address (address via as-needed EPAP increases)---and when there is no intermittent ventilatory undershoot to address (address via as-needed IPAP increases).

I would personally find it much more confusing if a titration protocol started high enough to guarantee iatrogenic problems in a subset of the patient population. In general sound titering procedures start low enough to avoid introducing problems with that very first experimental iteration.

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Re: ASV Part 3 - My Rocky Road from CPAP to ASV Therapy

Post by Grand-PAP » Mon May 07, 2012 12:02 pm

Hi -SWS,

What you say makes perfectly good sense and obviously you know a great deal more about it than I do. The only reason for my comment was because I "thought" bi-level in general, and perhaps ASV in particular, would be for people for whom straight CPAP (and possibly APAP) didn't work. Plus I "guess" I have always assumed that bi-level was most often prescribed when higher pressure levels were needed. But, I guess going back to your explanation, "starting" at EPAP 4cm + 0 PS, would still make sense to avoid problems and then increase the pressure as the titration required.

Thanks!

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Re: ASV Part 3 - My Rocky Road from CPAP to ASV Therapy

Post by -SWS » Mon May 07, 2012 12:17 pm

Well, the treatment premise of ASV is to deliver only as much IPAP as needed, to avoid ventilatory overshoot which is often inherently destabilizing. Ventilatory overshoot starts the domino effect in hypocapnia-triggered patients. The augmented treatment premise of ASV Advanced is to additionally deliver only as much EPAP as needed, again to avoid destabilizing central control in those patients who are so inclined.

But looking at your own improved results of Min PS =0, why wouldn't that have been a good starting place for your own titration protocol? If increasing Min PS during a titration protocol introduces problems, then the escalating iatrogenic pattern can be more readily discerned. Titrations start low and gradually scale up to avail simple or complex patterns of escalating improvement and/or problems....