Central mystery - New sleep study

General Discussion on any topic relating to CPAP and/or Sleep Apnea.
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rocklin
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Re: Central mystery - New sleep study

Post by rocklin » Mon Jan 02, 2012 4:57 pm

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Hi Mary Z!

Trust you had a reasonably entertaining new year.



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Mary Z wrote: I continue to have an AHI in the teens, but since I have no O2 desats (measured in the lab and overnight twice at home) the doctor said my apneas would not hurt my heart.
Your doctor is an idiot.

Uh, imho . . . of course.

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Here's a quicky experiment, should open his eyes.

Bring a pulse-oximeter and a . . . plastic bag . . . to your next visit with your doctor.

Oh, 30 seconds a pop should do the trick, hey, we don't want to kill the guy!

(rimshot!)



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-SWS
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Re: Central mystery - New sleep study

Post by -SWS » Mon Jan 02, 2012 6:42 pm

rocklin wrote:
Mary Z wrote: since I have no O2 desats (measured in the lab and overnight twice at home)

Here's a quicky experiment, should open his eyes.

Bring a pulse-oximeter

How will bringing a pulse oximeter to the sleep doctor's office teach him something he isn't already well-versed in?

Don't you suspect the doctor already demonstrated a grasp of hypoxemic risk by arranging Mary's previous oximetry that resulted in no desats?

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rocklin
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Re: Central mystery - New sleep study

Post by rocklin » Tue Jan 03, 2012 3:47 am

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Hi SWS!

I trust you had a swinging New Year.

(wink, wink, nudge, nudge)
-SWS wrote:
How will bringing a pulse oximeter to the sleep doctor's office teach him something he isn't already well-versed in?
Ah, but that's the point, old chap, that sleep doctor clearly doesn't know the first thing about oximeters.

Or, more accurately, he's not personally versed in oximeter ballistics.

Or he wouldn't make such stupid statements.

I know that some of you CPAPtalk oximeter freakazoids know exactly what I'm talking about.



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-SWS
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Re: Central mystery - New sleep study

Post by -SWS » Tue Jan 03, 2012 11:01 am

rocklin wrote: Ah, but that's the point, old chap, that sleep doctor clearly doesn't know the first thing about oximeters.
Well Mary spoke of three overnight oximtery collections that each returned no desaturatons. How does that reflect poorly on the doctor?

JimDB
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Re: Central mystery - New sleep study

Post by JimDB » Tue Jan 03, 2012 4:30 pm

-SWS wrote:
rocklin wrote: Ah, but that's the point, old chap, that sleep doctor clearly doesn't know the first thing about oximeters.
Well Mary spoke of three overnight oximtery collections that each returned no desaturatons. How does that reflect poorly on the doctor?
I believe you're posting in the wrong topic!

Jim

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rocklin
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Re: Central mystery - New sleep study

Post by rocklin » Tue Jan 03, 2012 7:47 pm

-SWS wrote:Well Mary spoke of three overnight oximtery collections that each returned no desaturatons. How does that reflect poorly on the doctor?
Try this simple experiment.

1. Put an oximeter on your finger. Let it warm up and stabilize.

2. Inhale, and then hold your breath for 30 seconds. Use a wristwatch.

3. Check your oximeter. Should be no change.

4. Give yourself another 30 seconds to recover.

5. Exhale, then hold your breath for 30 seconds. Again, use a wristwatch.

6. Check your oximeter. See how many of these cycles it takes before it migrates two points downwards and stays there.

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Meanwhile, how ya feeling?

If you're a deep-sea free-diver: no problem

But if you're middle-aged or older, not in the greatest shape, each of these breath holds will become more and more harrowing, especially the exhales and holds.

You'll likely see that it takes quite a while before these cycles affect your saturation by two points.

Now compare the feeling you have now with that of having to pee.

For many people, if they are sleeping, and it's past time too urinate, they will often dream of having to urinate, and eventually wake up.

It's not hard to extrapolate that "uncomfortable" feeling to the very panicked feeling you get when you can't breath, or hold your breath too long and too often.

That a current day RRT doesn't see "the change in sleep architecture" on their screen, is, imho, meaningless.

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I believe that the current metrics for measuring sleep architecture in a standard sleep lab are pretty primitive.

There is vastly more to sleep than the stages described in the now out-of-date literature.

Research sleep labs often have 64 channels of info, and, in a few labs, they have a CT or an MRI geared to measure glucose uptake via a titrated contrast media.

Plus other goodies, both now, and being developed.

So, without hard evidence behind me (yet!), I think it's safe to make the bet I'm making.

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No desats, and no observed fractures of SA doesn't automatically translate into restful, restorative sleep.

Krakow's research associate told me as much. They had patients with what the RRTs thought was a perfect night, at least it was from the perspective of the current diagnostics.

But when the patient awoke in the morning and they asked him how GGGGgggreat! he clearly must feel, they were shocked to see how often the answer was along the lines of: "I feel awful".

And this was using their top-of-the-line, breath-for-perfectly-sinusoidal-breath ResMed ASV protocol.


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-SWS
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Re: Central mystery - New sleep study

Post by -SWS » Tue Jan 03, 2012 8:08 pm

Rocklin, I honestly think your methodology and conclusion are both flawed. You equate your 30-second breath holding experients with what happened between Mary's pshysiology and her PAP machine.

It's not uncommon for home PAP machines to overscore AHI. It's more common for home PAP machines to overscore HI in particular. CPAP manufacturers don't even publish sensitivity and specificity estimates for mediocre hypopnea scoring. Furthermore, it's common for legitimate residual A&H events---short and in relative isolation----to not result in clinical desaturations.

I don't think we can equate the doctor as being the idiot----simply because Mary's residual AHI and lack of desaturations failed to match the characteristics of your 30-second breath-holding experiments. The doctor didn't administer the oximetry during the PSG and the doctor probably didn't score her lack of clinical-event desaturations during the PSG. Rather at least two medical professionals were involved in that. More if you count the PSG-scoring software designers who ALSO failed to compute significant desaturations while Mary was using xPAP.

I'm sorry but your methodology and conclusion that insults the doctor just does not compute here.

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rocklin
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Re: Central mystery - New sleep study

Post by rocklin » Tue Jan 03, 2012 10:27 pm

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-SWS wrote:Rocklin, I honestly think your methodology and conclusion are both flawed.
Entirely possible.

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-SWS wrote:You equate your 30-second breath holding experients
Imho, I equated nothing.

My point was simple: a "stop & start breathing" patient will be agitated well before his bloods show significant desaturation.

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-SWS wrote:It's not uncommon for home PAP machines to overscore AHI.
1. Citation please.

2. If true, so what?

As I've posted here many times, the idea that an event must be ten seconds or longer, or it won't have an effect on you is . . . moronic.

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I could stand above you while you sleep during the diagnostic phase of a ss. I put my right hand over your mouth, and my left hand pinches off your nose.

I count to nine.

Let go and allow you gasp for breath.

The perhaps ten or twenty seconds later, I repeat my cut-off of your air.

Each time, I am careful not to lower your desat, or to wake you up.

I do this on and off throughout the night.

In the morning the RRT congratulates you, saying that you've scored a perfect AHI = 0.0

But the raccoon eye circles under your eyes, your listless affect, they all tell a different story.

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-SWS wrote:Rather at least two medical professionals were involved in that.

More if you count the PSG-scoring software designers who ALSO failed to compute significant desaturations while Mary was using xPAP.
So?

Since when do we judge the correctness of a protocol by the number of working stiff clinicians blindly following it?

If ten medical professionals are in a surgical theater where a wrongful amputation takes place . . . does that make it a rightful amputation?

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archangle
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Re: Central mystery - New sleep study

Post by archangle » Wed Jan 04, 2012 2:41 pm

I played with a pulseox for a while. Something must be different between doing it asleep or awake. People will get desats while asleep in a short apnea, 10-15 seconds. If I'm awake, I can't normally get a desat even holding my breathe for 30 seconds or so.

I usually can't hold my breath long enough to show a desat by holding my breath. I'm dying by the time SPO2 starts to drop. It seems inconceivable to me that I could hold my breath in my sleep long enough to cause a desat without waking up.

Yes, I know our brain works differently when asleep. Obviously, it does happen. I still think there's something else going on here and we're more susceptible to desats when asleep.

By the way, if you want to see a desat while holding your breath, exhale as fully as possible before your start to hold your breath. If your lungs are full, they're still giving your blood oxygen and removing CO2. I still find it really hard to hold my breath long enough to desat.

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