Clinical Trial News

Has anyone heard anything more about this? It looks interesting, though it was a very small trial.
https://newatlas.com/medical/first-huma ... asal-spray

Sleep2Dream wrote: ↑

Fri Dec 09, 2022 11:19 am

Has anyone heard anything more about this? It looks interesting, though it was a very small trial.
https://newatlas.com/medical/first-huma ... asal-spray

The term "very small trial" puts up a very large red flag.
The first principle of statistics is sample size.
It makes all the difference between feasible and utter nonsense.
In this case, results could be easily manipulated to get desired results.
---and most likely, were.

Sleep2Dream wrote: ↑

Fri Dec 09, 2022 11:19 am

Has anyone heard anything more about this? It looks interesting, though it was a very small trial.
https://newatlas.com/medical/first-huma ... asal-spray

Sounds promising.

I am never one to rush out and try a new med though. (that is just me). I don't buy the first model year of a new car either. Some long term data on safety and effectiveness would be needed for me to consider trying it.

I can see though that there are people much bolder than I, or those that have tried and failed at pap, who would be happy to try such a possible solution. I haven't read enough about it to know what mechanism it uses for effectiveness.

For now i will continue to feel lucky that I have something that works for me and prevents/minimizes further damage to my body due to deoxygenation. I am curious if this Apnimed drug will indeed work well enough to prevent the desats. Lets hope so, shall we?

Thanks for posting.

chunkyfrog wrote: ↑

Fri Dec 09, 2022 11:29 am

Sleep2Dream wrote: ↑

Fri Dec 09, 2022 11:19 am

Has anyone heard anything more about this? It looks interesting, though it was a very small trial.
https://newatlas.com/medical/first-huma ... asal-spray

The term "very small trial" puts up a very large red flag.
The first principle of statistics is sample size.
It makes all the difference between feasible and utter nonsense.
In this case, results could be easily manipulated to get desired results.
---and most likely, were.

Its actually something the australian healthcare system and researchers are working on. I believe, from what I could tell, that it was similar to our phase 1 drug tests in this country where first a small number of users try it out and then it proceeds to larger sample size. I don't believe there is anything nefarious going on wrt small sample size.

JMHO

But the link looks very much like an AD.
They are plainly looking for INVESTORS.
The product is not yet available--too many similar concepts collected a pile of money;
Then they DISAPPEARED.
BigPharma would have jumped on it in a New York minute if it looked promising.
If wishes were horses, we would be up to our hips in meadow muffins.

chunkyfrog wrote: ↑

Fri Dec 09, 2022 11:29 am

Sleep2Dream wrote: ↑

Fri Dec 09, 2022 11:19 am

Has anyone heard anything more about this? It looks interesting, though it was a very small trial.
https://newatlas.com/medical/first-huma ... asal-spray

The term "very small trial" puts up a very large red flag.
The first principle of statistics is sample size.
It makes all the difference between feasible and utter nonsense.
In this case, results could be easily manipulated to get desired results.
---and most likely, were.

https://journal.chestnet.org/article/S0 ... 4194-0/pdf

12 people, 2cmh2o improvement.

chunkyfrog wrote: ↑

Fri Dec 09, 2022 1:04 pm

But the link looks very much like an AD.
They are plainly looking for INVESTORS.
The product is not yet available--too many similar concepts collected a pile of money;
Then they DISAPPEARED.
BigPharma would have jumped on it in a New York minute if it looked promising.
If wishes were horses, we would be up to our hips in meadow muffins.

Yup, always dig down to the source material.

palerider wrote: ↑

Fri Dec 09, 2022 4:24 pm

chunkyfrog wrote: ↑

Fri Dec 09, 2022 11:29 am

Sleep2Dream wrote: ↑

Fri Dec 09, 2022 11:19 am

Has anyone heard anything more about this? It looks interesting, though it was a very small trial.
https://newatlas.com/medical/first-huma ... asal-spray

The term "very small trial" puts up a very large red flag.
The first principle of statistics is sample size.
It makes all the difference between feasible and utter nonsense.
In this case, results could be easily manipulated to get desired results.
---and most likely, were.

https://journal.chestnet.org/article/S0 ... 4194-0/pdf

12 people, 2cmh2o improvement.

Clinical trial registration.

Like I said.

I never said I think it would work.

I just recognize, especially after spending a few months on this board, that some people simply don’t survive the struggles of adapting to paps.

Looked to me like the research grants came from the aussie govt.

palerider wrote: ↑

Fri Dec 09, 2022 4:25 pm

chunkyfrog wrote: ↑

Fri Dec 09, 2022 1:04 pm

But the link looks very much like an AD.
They are plainly looking for INVESTORS.
The product is not yet available--too many similar concepts collected a pile of money;
Then they DISAPPEARED.
BigPharma would have jumped on it in a New York minute if it looked promising.
If wishes were horses, we would be up to our hips in meadow muffins.

Yup, always dig down to the source material.

I saw several published articles by the lead author (Osman). She’s been working to find a pharmaceutical approach to OSA for some time, from what I can tell.

The reason I don’t jump on it as though it’s a giant conspiracy is because novel pharmaceutical approaches have to start somewhere.

Interestingly the funding is coming from the aussie govt, which would also have an interest with thier nationalized healthcare to find a solution.

Hard to say whether a pharm based solution would be more cost effective. But if someone struggling with papping was able to benefit like the rest of us do with our papping via a spray- well then kudos.

lynninnj wrote: ↑

Fri Dec 09, 2022 8:40 pm

I saw several published articles by the lead author (Osman). She’s been working to find a pharmaceutical approach to OSA for some time, from what I can tell.

The reason I don’t jump on it as though it’s a giant conspiracy is because novel pharmaceutical approaches have to start somewhere.

Interestingly the funding is coming from the aussie govt, which would also have an interest with thier nationalized healthcare to find a solution.

Hard to say whether a pharm based solution would be more cost effective. But if someone struggling with papping was able to benefit like the rest of us do with our papping via a spray- well then kudos.

I have used my machine pretty religiously for something like 6 years now. I hate it. I didn't hate it at first, but I have come to loathe the damn thing. If another, non-hardware treatment could be found, I'd jump on it.

Sleep2Dream wrote: ↑

Sat Dec 10, 2022 9:14 am

lynninnj wrote: ↑

Fri Dec 09, 2022 8:40 pm

I saw several published articles by the lead author (Osman). She’s been working to find a pharmaceutical approach to OSA for some time, from what I can tell.

The reason I don’t jump on it as though it’s a giant conspiracy is because novel pharmaceutical approaches have to start somewhere.

Interestingly the funding is coming from the aussie govt, which would also have an interest with thier nationalized healthcare to find a solution.

Hard to say whether a pharm based solution would be more cost effective. But if someone struggling with papping was able to benefit like the rest of us do with our papping via a spray- well then kudos.

I have used my machine pretty religiously for something like 6 years now. I hate it. I didn't hate it at first, but I have come to loathe the damn thing. If another, non-hardware treatment could be found, I'd jump on it.

Understandable.

I typically avoid pharmaceuticals because they either simply act ad a bandaid (in many cases), treat a symptom and not a cause, or create side effects that you often wind up chasing with another pharmaceutical.

I’m not saying they’re all bad. I’m just saying, I try to avoid it whenever possible.