A psychiatrist thinks an OSA patient has also hypochondria

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Re: Hypochondriac: what my psychiatrist thinks I might have

Post by robysue » Mon Dec 05, 2016 4:49 pm

papzombie wrote:
My guess is that you simply dislike "stale" or "stagnant" air, and having the window open allows for fresh air to come into your bedroom. It's not that the 'fresh' air has more oxygen; it's that the fresh air smells 'fresher' than the stale, stagnant room air. My guess is that what wakes you up when the window is not open is that you just get too hot since you are used to sleeping with the window open.
I don't know. About "stale"/ '"stagnant" or "used to fresh/cold air", then I have the following information: I grow up in a tropical country with a lot of air ventilation even in winter. When I moved to the colder part of Europe I started finding that I need window to open a bit, because windows here are so air-isolated.
If you did not grow up in an environment where windows were closed a lot of the time due to winter weather for long, long periods of time, then you would definitely be prone to finding the indoors air "stale", "stagnant" or simply "not fresh" during heating season.

And many of those who grow up with forced air heat in the winter often find that they enjoy opening up the house and airing it out whenever the outside air temps get slightly balmy in the winter time.

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by robysue » Mon Dec 05, 2016 5:19 pm

papzombie wrote:@ALL: Do you think what I experience is not real, or not that big ? Do I really have hypochondriasis like what the psychiatrist thinks ?
I think it's complicated.

I think you have some real problems with bad sleep that are independent of the OSA that seems to be well controlled by the CPAP. Whether some of the remaining bad sleep problems are directly being caused by physical stimuli from the CPAP triggering spontaneous arousals or not is not completely clear to me. There does seem to be a plain old "insomnia' component to what's going on, which is why starting the CBT-I is a good idea. You just need to be very reasonable in your expectations for CBT-I: It's not a quick fix and it does require some work. There also seem to be some anxiety problems going on: You are worrying a good deal about your O2 levels and the air feeling "heavy" when you wake up, but all evidence seems to point to your O2 levels being fine and your bedroom having enough ventilation, particularly if you do leave the window open. (And if you and your wife are both happy to leave it open, there's no reason not to.)

Some of your problems seem to be related to anxiety in general: It appears you are a worrier. What I mean by that is it appears that you can always find another thing to worry about when things are not going totally well and as you want them to go. You've put a lot of time and energy into trying to find a specific cause for your collection of symptoms, when it could just be that your brain became accustomed to sleeping very lightly with the untreated OSA and that the brain is having a harder than normal time learning that it can fully trust the CPAP machine to prevent the apneas and that it is now "safe" to get into a deep, restorative sleep as long as you are using the CPAP. And in this case, you've basically exchanged bad sleep caused by untreated OSA for bad sleep caused by sleep maintenance insomnia. It could also be that there are enough little bothersome stimuli coming from the CPAP and the mask that you are experiencing more spontaneous arousals than before you started, but the total number of arousals is way down. And it's just that the OSA arousals were the old "normal"---your brain had figured out a way of coping as best it could with them. But it's not yet figured out these new arousals and it doesn't yet understand things like the fact that it's ok to arouse just enough to scratch the nose when the mask makes it itch as long as you don't have to fully wake up to do it.

As for the sleep problems, you wrote:
I don't seem to be sleepy much after CPAP, only that I always have a feeling of not having slept enough: pressure at the forehead and top of the head, feel just weird.
Don't follow what you mean here. Are you ready and willing to get up after a night of CPAPing at your normal wake up time? Or do you have to be dragged out of bed because you are still exhausted and tired?

Pressure on the top of the forehead and top of head could be from the mask not being properly adjusted: Review the proper fitting instructions for your mask and make sure it's not over tight.
Why sleep not enough: the worst night (the night I wake up more often, remember more dream, feeling more tired immediately at waking up) is 100% correlated with the worst symptom of that weird feeling on my head; and the best night would only result in the slightest form of that weird feeling: a bit like I have drunk some alcohol early in the morning.
Can you describe the "weird feeling on your head" in more detail? Is it pain? If so, where is the pain located? Is it more an unsettled mood like disorientation from a bizarre and bad dream? And what do you mean that if feels "a bit like you have drunk some alcohol early in the morning"? Do you mean you are feeling tipsy? Or do you mean you are feeling hung over--can't focus on things and wishing the world would stop so that things don't seem quite so out of whack and painful to deal with?

And how did you feel before you started PAPing? Did you wake up feeling awful back then? Do you feel as awful now as you did then? Is the "awfulness" different in some kind way that you can describe in words?

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by papzombie » Tue Dec 06, 2016 7:04 am

Robysue: i'll spend time digest and reply to you. Thanks

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by chunkyfrog » Tue Dec 06, 2016 10:42 am

Robysue; that post should be stickied.
You are awesone!

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Re: Hypochondriac: what my psychiatrist thinks I might have

Post by robysue » Tue Dec 06, 2016 4:36 pm

papzombie wrote:
Without examining a great deal of your wave flow data on a breath-by-breath level, there's no good way to automatically say UARS explains your on-going problems. On the other hand, there's also no way to eliminate that as a cause of your symptoms.
Questions:
- The sleep doctor in Hospital C says the WatchPAT-200 is sensitive enough to also be able to detect UARS, and no UARS was found. Is that true ? Itamar website does not say so.
- The lung doctor in Hospital A says Apnea is also an Upper Airway Resistance, so when AHI is low it means UARS is also treated. I don't agree with him. Who is right here ? Or upon seeing that RERA is also low (~ 0.5), we can safely say UARS is not severe enough to cause my problem ?
You are using a PR System One Pro which records RERAs, which are the thing that causes problems in undiagnosed or under treated UARS. If your treated RERA index is consistently 1.0, then I'd say your machine is most likely taking care of any UARS problem that you might have.

I don't know enough about the WatchPAP-200 to know what it can and cannot detect.
A real PSG with your CPAP may or may not "synchronize my body movements to the awakenings". But it should show whether you are still experiencing a large number of spontaneous arousals while using the machine.
Question: Do you think a real PSG can do something to me that the WatchPAT-200 (measuring only the chest and the finger) cannot ?
Again, I am not an expert on what the WatchPAT can and cannot do.

My guess is that a real PSG with your CPAP would likely show the same thing the WatchPAT did: You have some problems with sleep maintenance that do not seem to be tied to your OSA (and/or UARS) not being well controlled by the CPAP. The data from a real PSG may show some correlation between body movements to wakes, but it might not show any correlation. The only body movements that they tend to track that show up in the summary data are PLMs and shifts in sleeping position.
"Is there another reason than the psycho-physiologist issue ?" Bad sleep has lots of causes. The CBT-I would help you get at whether any of your sleep related behaviors are making the problem worse than it needs to be.

Question: Do I need to purchase the Sleepio subscription ? It's 300 per year, a bit expensive.
I would suggest trying to find a real person to direct your CBT-I if possible. I don't know anything at all about the Sleepio program and so I cannot tell you whether it's worth the money or not.

If you must do CBT-I on your own without any help from a counselor, I'd first suggest working your way through a self-help book like Sound Sleep, Sound Mind by Dr. Barry Krakow. I'd also suggest keeping a sleep log for at least a couple of weeks, and maybe even for a couple of months. If you'd like a copy of the Excel spreadsheet that I use for my own sleep logs when I keep them, send me a PM with your email address and I'll be happy to send it to you.

If you cannot find a real, live CBT-I therapist and if working hard on self-help CBT-I for at least 2 months doesn't help you, then you can always revisit whether the Sleepio program is worth the $300 for you.

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by papzombie » Wed Dec 07, 2016 3:14 am

robysue wrote: Some of your problems seem to be related to anxiety in general: It appears you are a worrier. What I mean by that is it appears that you can always find another thing to worry about when things are not going totally well and as you want them to go. You've put a lot of time and energy into trying to find a specific cause for your collection of symptoms, when it could just be that your brain became accustomed to sleeping very lightly with the untreated OSA and that the brain is having a harder than normal time learning that it can fully trust the CPAP machine to prevent the apneas and that it is now "safe" to get into a deep, restorative sleep as long as you are using the CPAP. And in this case, you've basically exchanged bad sleep caused by untreated OSA for bad sleep caused by sleep maintenance insomnia. It could also be that there are enough little bothersome stimuli coming from the CPAP and the mask that you are experiencing more spontaneous arousals than before you started, but the total number of arousals is way down. And it's just that the OSA arousals were the old "normal"---your brain had figured out a way of coping as best it could with them. But it's not yet figured out these new arousals and it doesn't yet understand things like the fact that it's ok to arouse just enough to scratch the nose when the mask makes it itch as long as you don't have to fully wake up to do it.
That's correct, I'm a worrier and pessimist.

About arousals: It seems I am not a "sound sleeper", meaning that it takes much less time (say 30% comparing to normal persons) for me to change from sleeping to fully awake. That's noted by my wife. My wife got to know me after I started OSA, so probably my easily-awaken brain had been trained by OSA, and now that brain seems still to be too much alert.

I don't seem to be sleepy much after CPAP, only that I always have a feeling of not having slept enough: pressure at the forehead and top of the head, feel just weird.
Don't follow what you mean here.
...
Pressure on the top of the forehead and top of head could be from the mask not being properly adjusted: Review the proper fitting instructions for your mask and make sure it's not over tight.
The worse night, the more visible I see the weird feeling as described here: viewtopic/t81294/viewtopic.php?f=1&t=11 ... 0#p1103260
Are you ready and willing to get up after a night of CPAPing at your normal wake up time? Or do you have to be dragged out of bed because you are still exhausted and tired?
Like I said, it's easy for me to get up from bed (I need max 2-3 minutes to actually want to get out, comparing to my wife with 15-20 minutes), but I know I would have the brain functioning only 50%-70% .
Why sleep not enough: the worst night (the night I wake up more often, remember more dream, feeling more tired immediately at waking up) is 100% correlated with the worst symptom of that weird feeling on my head; and the best night would only result in the slightest form of that weird feeling: a bit like I have drunk some alcohol early in the morning.
Can you describe the "weird feeling on your head" in more detail? Is it pain? If so, where is the pain located? Is it more an unsettled mood like disorientation from a bizarre and bad dream?
During the whole morning: 9:30 til 12:30, I have a physical feeling on my forehead and head top: a bit like pressure, a bit like numbness. With that there comes a logical feeling: that my thoughts move around in my brain through fog. It seems like there is fog between the neurons, that one neuron does not "see" the other neurons easily, so the signal being transmitted need to reduce it's speed. And actually thinking speed is very low (one time I measure several times a simple calculation like 71-13 = 58 and see the duration of 17 seconds, this I could have done in 1-2 seconds at age 20 (now I'm 40))
And what do you mean that if feels "a bit like you have drunk some alcohol early in the morning"? Do you mean you are feeling tipsy? Or do you mean you are feeling hung over--can't focus on things and wishing the world would stop so that things don't seem quite so out of whack and painful to deal with?
The best night would only result in a light numbness in the mentioned area, just like what I feel when I'm a bit drunk.
And how did you feel before you started PAPing? Did you wake up feeling awful back then? Do you feel as awful now as you did then? Is the "awfulness" different in some kind way that you can describe in words?
No, the weird feeling on my head stays the same. CPAP only helps reduce sleepiness.

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by robysue » Wed Dec 07, 2016 7:32 am

Papzombie,

I'll write more tonight. It's going to be a very busy day for me.

Are you sure that your mask fit correctly? A lot of people will over tighten the head gear, and the pressure feeling you are describing could very well be from a mask that is too tight.

Brain fog? Most likely its because you are not yet sleeping deeply or continuously enough to get a really good night's sleep. It sounds like your brain is having a really hard time letting go of the "apnea vigilance" and relaxing into sleeping well with the CPAP machine. Again, CBT-I might help if part of the CBT-I focuses on the fact that you do use a CPAP.

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by papzombie » Wed Dec 07, 2016 4:08 pm

Hi Robysue,

Are you working full time ? If so, it's unbelievable how you spend time helping people here.
Are you fully "recovered" from OSA ?

Take care

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by papzombie » Wed Dec 07, 2016 4:49 pm

Also I forgot to mention: after 8 months of CPAP-ing on 9cm H2O, I still have this back pain at this location, after 0.5-1.0 hour after waking up this pain would disappear.

I know that normally there are 2 reasons
- After 10 years of tossing around during the night, now I could lie still on my back to sleep (my video record says I am at my back > 95% of the time)
- My lung/chest/something needs to work harder on this CPAP machine (no exhaling relief is present in this machine).

But after 8 months, is it abnormal ?

Image

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by robysue » Thu Dec 08, 2016 1:09 pm

papzombie wrote:
robysue wrote: Some of your problems seem to be related to anxiety in general: It appears you are a worrier.
That's correct, I'm a worrier and pessimist.
There's good worrying and there's bad worrying. If you are worrying about things that you can genuinely control and actively working on fixing those things, that's good worrying. But if you are worrying about things that you cannot control or cannot do anything about---particularly at the time you are actually worrying about them, that's bad worrying. And if you're doing a lot of bad worrying while trying to sleep, it aggravates the insomnia problems.
About arousals: It seems I am not a "sound sleeper", meaning that it takes much less time (say 30% comparing to normal persons) for me to change from sleeping to fully awake. That's noted by my wife. My wife got to know me after I started OSA, so probably my easily-awaken brain had been trained by OSA, and now that brain seems still to be too much alert.
This is a common problem in insomniacs. And untreated OSA adds to the problem. You are probably right: Your brain is still being too vigilant when you are asleep because it's having a hard time believing the OSA arousals are no longer happening frequently enough to matter AND because you've got a natural insomniac's problem of just giving in fully to a good, solid continuous sleep. And bad worrying can contribute to the problem.

I don't seem to be sleepy much after CPAP, only that I always have a feeling of not having slept enough: pressure at the forehead and top of the head, feel just weird.
Don't follow what you mean here.
...
Pressure on the top of the forehead and top of head could be from the mask not being properly adjusted: Review the proper fitting instructions for your mask and make sure it's not over tight.
The worse night, the more visible I see the weird feeling as described here: viewtopic/t81294/viewtopic.php?f=1&t=11 ... 0#p1103260
The headache pain you describe over on that thread sounds like a plain old garden variety tension headache. As for why it finally goes away around 13:00? I don't know, but tension headaches usually don't last all day.

Why would you be waking up with a tension headache most mornings? Could be from worrying. Could be that you are sleeping in a weird position. Could be you've got trigger points (small muscle knots) in your neck or back that are the real cause of the tension headaches and that your sleep position encourages those knots to form. And there's still the possibility that the mask straps are a bit too tight and putting a bit too much pressure on certain spots of your head.

As for the "brain fog" that accompanies the headaches: Chronic headaches of any sort can make it difficult to concentrate on what you really want to do. Pain, even dull pain, has a funny way of interfering with thinking clearly.
Are you ready and willing to get up after a night of CPAPing at your normal wake up time? Or do you have to be dragged out of bed because you are still exhausted and tired?
Like I said, it's easy for me to get up from bed (I need max 2-3 minutes to actually want to get out, comparing to my wife with 15-20 minutes), but I know I would have the brain functioning only 50%-70% .
Lots of people take a long time to become fully awake in the morning in terms of "brain functioning". And if you are getting up at a time that is not when your body wants to get up, it can take even longer.

What is your usual sleep schedule? When do you usually get to bed? When do you usually get up for the morning?

And if there was nothing at all forcing you to sleep on your usual sleep schedule, when would you prefer to go to bed? And when would you prefer to get up? Are you more of a night owl or a morning lark?
Can you describe the "weird feeling on your head" in more detail? Is it pain? If so, where is the pain located? Is it more an unsettled mood like disorientation from a bizarre and bad dream?
During the whole morning: 9:30 til 12:30, I have a physical feeling on my forehead and head top: a bit like pressure, a bit like numbness.
Any chance you are sleeping in a weird position that puts pressure somewhere on your shoulders, arms, or back in an unnatural way?
With that there comes a logical feeling: that my thoughts move around in my brain through fog. It seems like there is fog between the neurons, that one neuron does not "see" the other neurons easily, so the signal being transmitted need to reduce it's speed. And actually thinking speed is very low (one time I measure several times a simple calculation like 71-13 = 58 and see the duration of 17 seconds, this I could have done in 1-2 seconds at age 20 (now I'm 40))
I think you are conflating two issues: The physical feeling is most likely coming from the physical position you were sleeping in. The "logical feeling" is most likely coming from whether you are waking up and getting up at a time that best fits your circadian rhythm and/or whether you are just someone who takes a long time to "wake up" on a typical morning.

As for the actual time it takes to do a simple arithmetic problem: I'm not sure that's the best test of "thinking ability." And I think that you've added this to your long list of things to worry about. In other words, if you were less worried about how long it takes to your brain to "think" in terms of things like simple calculations, the better your thinking might actually become. In other words, you may be asking your brain to do too many things at one time because you are asking it to do the worrying about the thinking/calculation at the same time as measuring the time the thinking/calculation takes to do and at the same time as doing the thinking/calculation.


And how did you feel before you started PAPing? Did you wake up feeling awful back then? Do you feel as awful now as you did then? Is the "awfulness" different in some kind way that you can describe in words?
No, the weird feeling on my head stays the same. CPAP only helps reduce sleepiness.
[/quote]The only thing the CPAP is designed to do is to treat the OSA. And if the CPAP has reduced the sleepiness, then it's likely the CPAP is doing its job (and doing it well) when it comes to keeping the OSA under control. My guess is that what you are describing as the "weird feeling on your head" is probably coming from chronic tension headaches. You may want to talk to your doctor about whether you might have chronic tension headaches, and if so, what kinds of things can be done to bring them under control.

Again just to talk about my own medical history for a bit: I have suffered from a number of different kinds of chronic headaches for most of my life---going all the way back to my childhood. I have been officially diagnosed with chronic migraines, chronic tension headaches, and TMJ headaches. I also have seasonal sinus headaches, and a number of things can trigger either migraines or tension headaches including weather changes, noise, light, forgetting to eat a meal, eating too much, too much caffeine, too much alchohol (which can be as little as drinking one full 12 oz bottle of beer or one mixed drink), too much variability in my sleep schedule, and worrying too much about things I can't do anything about. Shortly after starting CPAP, the migraines exploded in terms of frequency and started manifesting themselves as severe vertigo as well as headaches and the TMJ also exploded. It took a good 6-8 months of work on both of them to bring them properly under control. About 12-15 months, the tension headaches exploded. I and my doctor are still working on getting the tension headaches properly controlled. So-called "trigger points" seem to be the root cause of my tension headaches, and so I get regular trigger point injections designed to help release the muscle knots. I also get regular massages for the same reason. With the trigger point injections and the massages, the frequency of the tension headaches has been reduced, but I'm not where we (me, the PA, and the massage therapist) want me to be yet. We're making progress, and in time I am confident that my tension headaches will be as well controlled as my migraines and TMJ headaches are and I will once again be mostly pain free.

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by robysue » Thu Dec 08, 2016 1:15 pm

papzombie wrote:Also I forgot to mention: after 8 months of CPAP-ing on 9cm H2O, I still have this back pain at this location, after 0.5-1.0 hour after waking up this pain would disappear.
Is the pain correlated with breathing? Or is is muscular pain or plain old back ache pain?

Pain correlated with breathing or pain that seems to be related to your chest in any way should be investigated by your primary care physician. Plain old muscular pain or back ache pain is more likely explained by the position you are choosing to sleep in OR possibly that your mattress is not providing the appropriate kind of support for you back.
I know that normally there are 2 reasons
- After 10 years of tossing around during the night, now I could lie still on my back to sleep (my video record says I am at my back > 95% of the time)
- My lung/chest/something needs to work harder on this CPAP machine (no exhaling relief is present in this machine).
Your PR System One CPAP Pro has a form of exhalation relief called "Flex". If you believe that exhaling is too hard, turn Flex on and experiment with it.
But after 8 months, is it abnormal ?
It depends on what kind of pain you are actually experiencing.

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by Hydraulix989 » Thu Dec 08, 2016 9:58 pm

A few thoughts:

RERAs do not accurately get tracked by even the System One; the name is telling: Respiratory Effort Related Arousal. The only way you can actually tell if there is the Arousal (an A) is with an EEG. Usually, that means a PSG (or a Zeo). The RERAs recorded by PAPs only check for "clipping" (or some other pattern) in the breathing waveform, but they can't _possibly_ check for the very necessary arousal component that designates a RERA.

Case in point: My AHI (including RERAs) was well below 1.0 every night on PAP, but my Stanford PSG showed ~15 RERAs per hour.

I visited the best sleep apnea surgeon in the world, Dr. Kasey Li in Palo Alto/Stanford. We're a bit at the edge of medical science here, but he sees tons of patients on PAP who still have residual daytime sleepiness. According to him, PAP gets you from feeling 2/10 to 5/10 or 6/10, but not all the way to 10/10. His hypothesis is that sleep requires natural rest, and the feeling of wearing a machine and the mask is very unnatural. Of course, sleep science is still very much in its infancy, so there hasn't been any conclusive results or studies supporting this hypothesis yet, but he very much believes it to be true (along with some of his other colleagues including Guilleminault).

I really suggest wearing a dental appliance instead of PAP. I actually have worse AHI with mine, but I feel MUCH more rested when I wake up.

About the back pain: You also HAVE to fix that. I suggest exercising (including strengthening and weight training), stretching, and watching your posture. Try using a standing desk, and if you can get a $20 foam roller used for physical therapy on Amazon to roll on every night, that will help a lot, too. I had pretty bad back pain for a while, and it actually helped my sleep tremendously once I started taking care of it. Not to mention, the exercise actually does wonders for your mood and the quality of sleep as well, especially if you can go out and do some cardio like jogging a mile 3-5 days a week.

Now, I look at your psychological symptoms, and they look like they are all caused by poor sleep: the headaches, the anxiety, the depression, the slow-thinking, the "brain fog" (yes, even Dr. Li agrees). CBT may help with the symptoms, but you're not treating the real "root cause," which is the sleep deprivation. You might also have good luck with an SSRI, since they reduce the time spent in REM sleep as a side effect, where your apneas are most severe.

Remember, you're on a web site where the only people on it are the people who had the most success with CPAP. Most people who had bad experiences give up and leave. The people who CPAP helps the most are the ones who stick around and become frequent posters.

Hope that helps.

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Re: Hypochondria: what my psychiatrist thinks I might have

Post by 49er » Fri Dec 09, 2016 3:52 am

Hi Hydraulix989,

Welcome to the forum.

Regarding RERAS, making the comparison between what they show after using the machine and a sleep study that shows the figure when it is untreated is not a valid comparison.

Interesting comments by Dr. Li. Unfortunately, when I tried a dental device, my sleep felt more unnatural than it did with a mask. When I woke up with it in my mouth, I felt like I had to take it out yesterday. And it greatly freaked me out that my bite already was out of alignment after just wearing it for three hours.

Of course, if someone has greatly struggled with pap therapy no matter what they have tried, this should definitely be the next step. I am glad it is working well for you.

Regarding taking an SSRI, you are aware that many times, they cause insomnia right?

Much continued success regarding wearing your dental device.

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papzombie
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Re: Hypochondria: what my psychiatrist thinks I might have

Post by papzombie » Fri Dec 09, 2016 9:54 am

@Robysue: i'll reply to you this weekend

@Hydraulix: can you register and post more info here ?
- Is your ~15 RERA per hour as captured by the PSG much different from the number of RERA captured by your xPAP machine ?
- What dental appliance do you use ?
- Can you point me to a research paper saying that PSG is more accurate in capturing RERA than the xPAP machine ? I'll need such scientific evidence to be able to convince my doctors.

A PSG done by the WatchPAT-200 has shown that my RERA index is 3.1, because my RDI (Respiratory Disturbance Index) is 4.0, while AHI is 0.9. Now the thing is: i am not sure if that WatchPAT-200 can detect the RERAs as well as a traditional PSG.

_________________
Mask: Mirage™ FX Nasal CPAP Mask with Headgear
Additional Comments: CPAP pressure 9 H2O, Machine = PR System One REMstar Pro CPAP Machine with C-Flex Plus
AHI = 0.7, wake up 3 times per hour, always tired

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sypark
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Re: Hypochondria: what my psychiatrist thinks I might have

Post by sypark » Fri Dec 09, 2016 10:48 pm

Papzombie,

Someone asked me to give some insights into your posting.

Going though your comments and the entire post, a few thoughts come to mind:

1. You're right in that high RERAs could explain your persistent symptoms despite a relatively low AHI. The problem with RERAs is that on sleep studies, it must meet the 10 seconds threshold to be counted as a RERA. The formal definition is, "A series of respiratory cycles of increasing/ decreasing effort or flattening, recorded by nasal manometry and leading to an arousal that cannot be defined as apnea or hypopnea. Duration ≥ 10 sec."

So even if you treat every RERA with CPAP, you can still have significant partial obstructions lasting less than 10 seconds with EEG arousals. We see this in CPAP titrations, where the AHI can be 1 or 2, but you still see lots of RERAs and even arousals without RERAs. Even the very mild flow limitations can cause EEG arousals from sleep.

2. If you have liver dysfunction, that in itself can aggravate various medical problems that can feed into fatigue and brain fog. It's interesting to note that OSA is has a strong independent association with nonalcoholic fatty liver syndrome with elevated liver enzymes.

3. As robysue mentions, some of your symptoms may be related to a variation of your headache/migraine/TMJ issue, which can also be aggravated by microarousals and fragmented sleep. CPAP is good at treating apneas and hypopneas, but not as good in treating RERAs, and even worse at treating more subtle breathing problems.

4. For some people with hypersensitive nervous systems, having the mask on the face and with air blowing in can cause arousals.

5. Even in patients that have undergone definitive jaw surgery (MMA) where the AHI drops from 60 to 1, some patients don't feel any better. These patients almost always have persistent severe soft tissue obstruction either at the tongue base, or soft palate. I'm also seeing an increasing number of people with epiglottic collapse that will give you quick arousals, which CPAP won't address. Another anatomic oddity that I'm seeing is when the soft palate backs up into the nose, with sudden blockage during mid-nasal exhalation, causing frequent arousals. In the same way, even when CPAP seems to be "working" there may be subtle but persistent obstructions that can cause frequent arousals not coming from apneas or hypopneas. Once you've ruled out these possibilities, then you have to assume that your symptoms may be due to something going on in your brain. We know from functional MRI studies that there can be significant damage to multiple areas of the brain, which won't show up on routine MRI exams.

6. Yes, it's very important to address all the sleep hygiene issues mentioned, as well as to consider CBT-i.

7. Sometimes, you have to try another form of therapy, such as an oral appliance, if you're a candidate. However, for both CPAP and oral appliances, it's vitally important that your nose is wide open. If you have the epiglottis or soft palate issue that I mentioned previously, dental appliances won't work either in general.

It's difficult to troubleshoot without a in-office exam and evaluation. However, there are some of the common things to think about when you have persistent symptoms despite "optimal" CPAP therapy.

Hope this helps...
Steven Y. Park, MD
Blogger, sleep physician, and sleep surgeon
Author of the book, Sleep, Interrupted: A physician reveals the #1 reason why so many of us are sick and tired.
http://doctorstevenpark.com.