CPAP Basics - 10 - NPSG

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mollete
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CPAP Basics - 10 - NPSG

Post by mollete » Wed Apr 24, 2013 3:37 am

Sleep Architecture 101

These are examples of hypnograms showing sleep architecture during a full night's sleep.

The first example represents normal sleep. Sleep progresses from wake, through light sleep (Stage 1 and 2), followed by deep sleep (Stages 3 & 4), and finally a REM period. This is called a Sleep Cycle, and takes about 90 minutes to complete. There are usually 4-6 Sleep Cycles per night. Most deep or delta sleep occurs in the first Sleep Cycle. The duration of REM periods increase as the night goes on. Normal sleep stage percentages are Stage 1 5%, Stage 2 60%, Stage 3 & 4 combined 20%, and REM 20%. Delta sleep generally decreases as a function of age:

Image

This example represents someone with OSA. After sleep onset, the patient moves back and forth from Stage 1 to Stage 2 sleep. Stage 1 sleep is simply a transition stage to quality sleep and should only appear at the beginning of the night. It has virtually no value as far as restorative sleep goes. It is should not appear to any great degree once bona fide sleep begins. There is no delta sleep whatsoever. REM sleep is 19.9%. The patient is aroused to wake at least 10 times. There is some continuous stage 2 and REM sleep, but overall this is fairly poor quality sleep, with frequent disruptions caused by OSA:

Image

This example shows a patient with a large quantity of delta sleep (20.8%) and REM sleep (33.8%). Sleep is fairly continuous. This patient will be well rested in the morning. This patient is the one from example 2 during his CPAP titration. This greater than normal quantity of delta and REM sleep is termed Rebound Phenomenon. With regular use, the CPAP user will move to a more normal sleep architecture as the "sleep debt" is paid off. This usually occurs in a day or so. This also serves to explain why some people think they slept so well in the lab, but then do poorly at home. It's not that they're doing poorly, they're actually now approaching normal architecture, the aggravating factor is now gone:

Image

This example represents a Split-Night study. Initially, there is a very disrupted, light sleep pattern, that turns into prolonged REM after application of CPAP. There are areas of sustained sleep, but there are still areas of disrupted light sleep. This patient also had Periodic Limb Movements which continued to disrupt sleep even though respiratory events were well-controlled on CPAP:

Image

There should probably be about 40-50 stage shifts in a normal, healthy patient not troubled by lab effect (the test itself can drive up the stage shifts). Most references are looking at about 7 stage shifts per hour, give or take. There should be few, if any awakenings, perhaps in the neighborhood of like "2". An awakening is a sleep disturbance that lasts >15 seconds, as opposed to an arousal, which lasts 3 - 15 seconds. Consequently, awakenings are highly disruptive to sleep.

(Hypnograms generated prior to the new standards for NREM, which now combine Stages 3 & 4.)

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Re: CPAP Basics - 10 - NPSG

Post by zoocrewphoto » Wed Apr 24, 2013 3:45 am

So, the example of the split night study looks a lot like mine.

Image

Since the deep sleep is mostly in the first cycle, does this mean that I probably wasn't getting any, ever? I clearly didn't get any during the diagnosis phase at all. Was that likely to be going on every night, for years on end?

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Re: CPAP Basics - 10 - NPSG

Post by Pugsy » Wed Apr 24, 2013 3:49 am

Thank you Mollete.. This makes it much easier to explain and show how the sleep cycles can be messed up.
I suspect I will be needing this in the future so I saved the link to this page and expect to referring newbies back to it often.

Question for you? What are your thoughts on "sleep debt"? Do you think it is as long lasting as some people want to say it is?
Like weeks and months? As in assuming that with optimal cpap therapy (not crappy therapy adding to sleep debt) it takes weeks and months to erase sleep debt?

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Re: CPAP Basics - 10 - NPSG

Post by mollete » Wed Apr 24, 2013 4:17 am

In re: Sleep Debt (from a prior post)(as are most of these entries):

(1) There are a number of components that go into making you "feel better" as you treat you OSA. Paying off the sleep debt is only one component of that.
(2) If you're not sleeping more than your base sleep requirement, the answer as to when you pay off your sleep debt is "never".
(3) It also depends on how big your debt is.

As noted in the Dement work, "The Promise of Sleep", there are number of ways to determine your basic sleep needs, and then you can do a running total of your sleep debt. But to skip ahead, there are several methods to estimate your sleep debt at the moment of your transition to CPAP and now. The easiest of these is to use the Epworth Sleepiness Scale. This method gives you a number that quantifies your level of sleepiness and estimates your sleep debt. You probably did this prior to your sleep studies, if you don't remember the number, call the Manager of the Sleep Laboratory and I'm sure he can find it for you. It looks like this:

Use the following scale to choose the most appropriate number for each situation:

0 = would never doze or sleep.
1 = slight chance of dozing or sleeping
2 = moderate chance of dozing or sleeping
3 = high chance of dozing or sleeping

Situation Chance of Dozing or Sleeping

Sitting and reading ____
Watching TV ____
Sitting inactive in a public place ____
Being a passenger in a motor vehicle for an hour or more ____
Lying down in the afternoon ____
Sitting and talking to someone ____
Sitting quietly after lunch (no alcohol) ____
Stopped for a few minutes in traffic while driving ____

Total score (add the scores up) ____

Dr. Dement equates the Epworth Score thus:
0-5 Slight or no sleep debt
6-10 Moderate sleep debt
11-20 Heavy sleep debt
21-25 Extreme sleep debt

The time needed to pay off the sleep debt depends on the size of the bill, whether it will be days or weeks (actually the sleep debt concept only goes out about two weeks, that's the extent of documented study. It probably levels out at some point for a number of reasons).

Anyway, get your score pre-test, that'll give you the size of the bill, then rate your Epworth Score now, and that should give you a rough idea on how many payments you have left.

"THE PROMISE OF SLEEP", William C. Dement and Christopher Vaughan
Delacorte Press, 1999

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Re: CPAP Basics - 10 - NPSG

Post by Pugsy » Wed Apr 24, 2013 4:49 am

Yeah, I remember the test...don't remember the exact numbers but was around 15 or so I think.
Now I would be hard pressed to score a 1 or 2 and that doesn't surprise me.

Here's my example. Once I got my pressures tweak to take care of the stubborn REM events (BTW got sleep doctor's blessing for my dial a winging) the bulk of my OSA symptoms disappeared but I still felt the strong need to nap in the late afternoon. Never could quite shake it or figure out anything that was the trigger (like diet or some other factor).
At least I wasn't getting up at 7 AM and nodding off at 9 AM but I never could shake the afternoon sleepiness.
When I made the change to bilevel (you know that experiment) the afternoon sleepiness disappeared immediately. Comparing the software reports...no real changes except that I noticed that my hours of sleep (overall averages) increased from 7 to 7 3/4 or 8 hours of sleep if left to my own body to set the time frame. So the only thing I could assume is that my body really appreciated the extra 45 minutes of sleep. That and/or maybe my body liked the overall comfort of the bilevel which was a strong factor in my preference for it.

So maybe those 2 years I was averaging around 6 1/2 to 7 hours of sleep I wasn't quite paying off sleep debt for whatever reason and with 7 1/2 to 8 hours or so I tend to get the sleep dept pad off?????

Pre Cpap I know the sleep was horribly fractured..waking up to pee about every hour on the hour with a full (to painful full) bladder and lots of other awakenings due to pain and generally crappy sleep tossing and turning and snoring so bad my throat felt like I had strep throat..
Post CPAP therapy...the only thing left was the afternoon sleepiness that bugged me. Energy levels...well heck, I am not a spring chicken and have never ever been a morning person even pre OSA so I didn't ever expect cpap to make me into something I never was to start with.

Is it possible that the 2 years on APAP with quite acceptable reports and average hours of sleep around 7 were just not quite enough for my body to pay off sleep debt totally and the around 8 hours gets the slate erased?
I am up early today (3 AM wake up with 5 1/2 hours sleep) due to some extra bad pain. So I know I will likely feel drowsy this afternoon but I know from past experience that if can get around 8 hours of sleep tonight that I will be back to my normal self tomorrow.

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Re: CPAP Basics - 10 - NPSG

Post by mollete » Wed Apr 24, 2013 5:01 am

Certainly sounds like there's a few more things underfoot!

Interestingly, Pain is coming up soon in the series!

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Re: CPAP Basics - 10 - NPSG

Post by mollete » Thu Apr 25, 2013 2:26 am

zoocrewphoto wrote:Since the deep sleep is mostly in the first cycle, does this mean that I probably wasn't getting any, ever? I clearly didn't get any during the diagnosis phase at all. Was that likely to be going on every night, for years on end?
I think that would be a safe assumption.

That said, I think that, technically, a lot more older people get more SWS than their NPSG shows. SWS is scored by (among other things) the height (amplitude) of the EEG, which often decreases as they age (or fry their brain with drugs, booze, etc.).

"IMHO", the 2008 or 2012 "Da Rules" book should have allowed an amplitude "handicap" for age, or perhaps a NREM2△ stage (low frequency NREM2) to account for this phenomenon, and give credit where credit is due.
Last edited by mollete on Thu Apr 25, 2013 2:29 am, edited 1 time in total.

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Re: CPAP Basics - 10 - NPSG

Post by mollete » Thu Apr 25, 2013 2:27 am

BTW, here's a "normal" architecture using the New Rules:

Image

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Re: CPAP Basics - 10 - NPSG

Post by NotLazyJustTired » Thu Apr 25, 2013 6:53 am

Thanks again for an excellent thread. I had a cursory knowledge of this topic but this deepens that quite a bit more. My hypnogram unfortunately only shows REM sleep, the other stages apparently were not scored? There are other statistics though that support a fragmented sleep architecture. My sleep stage pie graph was broken down as 15.3% N1, 70.0% N2, 0.2% N3, 14.5% REM. Based on that it seems I really didn't get any delta sleep and most of my time was spent in stage 2. It also reports Total Stage Changes at 137 and Awakenings at 43. Sleep efficiency was 64.6%. So, yeah, a pretty crappy night.

Can you tell us more about sleep efficiency and what normal looks like?

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Re: CPAP Basics - 10 - NPSG

Post by khauser » Thu Apr 25, 2013 7:22 am

mollete wrote:BTW, here's a "normal" architecture using the New Rules:

Image
I was wondering why the REM line was above the Wake line ... was that just 'cause' or was there a better reason?

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Re: CPAP Basics - 10 - NPSG

Post by NotLazyJustTired » Thu Apr 25, 2013 7:30 am

khauser wrote:
mollete wrote:BTW, here's a "normal" architecture using the New Rules:

Image
I was wondering why the REM line was above the Wake line ... was that just 'cause' or was there a better reason?
I've noticed that before when researching the subject on the web. My speculative answer is that N1 and N2 are the typical next stages from REM sleep (even Wake). So that is the more "natural" place to put it?

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Re: CPAP Basics - 10 - NPSG

Post by -SWS » Thu Apr 25, 2013 9:50 am

mollete wrote: Interestingly, Pain is coming up soon in the series!
Trigeminal neuralgia and fibromyalgia---not one but two pain disorders here. Arthritis is so minor I'm not counting that. Plenty of alpha-wave intrusions during sleep according to my tech.

Thanks in advance for the section on pain. I'll be on the lookout for that!

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Re: CPAP Basics - 10 - NPSG

Post by SleepingUgly » Thu Apr 25, 2013 3:20 pm

So are you saying that sleep debt can take up to 2 months to "pay off"? I thought I'd read somewhere that about 20 hours of debt is all that accrues. If this whole "sleep debt" thing is a real phenomena, how can one assess the impact on EDS of any particular setting (whether on PAP or a MAD) without waiting for months to see if it improves?
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Re: CPAP Basics - 10 - NPSG

Post by DoriC » Thu Apr 25, 2013 9:59 pm

mollete wrote:
zoocrewphoto wrote:Since the deep sleep is mostly in the first cycle, does this mean that I probably wasn't getting any, ever? I clearly didn't get any during the diagnosis phase at all. Was that likely to be going on every night, for years on end?
I think that would be a safe assumption.

That said, I think that, technically, a lot more older people get more SWS than their NPSG shows. SWS is scored by (among other things) the height (amplitude) of the EEG, which often decreases as they age (or fry their brain with drugs, booze, etc.).

"IMHO", the 2008 or 2012 "Da Rules" book should have allowed an amplitude "handicap" for age, or perhaps a NREM2△ stage (low frequency NREM2) to account for this phenomenon, and give credit where credit is due.
Such good information! Maybe now I can accept that reality and stop trying for some of those really clean reports I see here. His therapy even with the SWS has made such a difference in his quality of life and for that I'm grateful.

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Re: CPAP Basics - 10 - NPSG

Post by zoocrewphoto » Fri Apr 26, 2013 12:18 am

What does SWS stand for?

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