I got my reader and software today and had same problem and came across your post. To get up and running I disconnected the reader from USB port - then followed directions that came with reader again to "Start the Set-Up" process again - this time though the wizard detected that the drivers were alr...

I cranked humidifier up to 5 and that seems to have helped cough (also break from work) Now back at work cough has started a bit again - probably just related to extreme temperature swings here in Chicago

I started treatment about three weeks ago and have had a bad cough and have been coughing up stuff ever since (but sleeping a lot better and more) I have always had very mild asthma - could the machine be irritating it somehow?

M Series with Heated Humidifier