I'm not sure where to start, so I'm going to throw a few things at the wall here and I hope maybe people will have some ideas of what I can check first:
1. I'm working under the assumption that my settings are effective (I haven't found any article discussing what is "good" for all the variables that SleepyHead tracks--I'm just going off of how I feel). The below is a capture of my stats from SleepyHead:

2. I sometimes wake up with my nose being itchy. I generally have the humidifier around level 4-5, and I don't notice any condensation.
3. It's hard for me to go to sleep unless I hit the ramp button, I'm wondering if my settings are too high because I do feel the higher pressure wakes me. I note the original titration was done when I was about 20 lbs. heavier (I was 210 lb., now down to 190 lbs.).
4. Mask fit can be improved, but I don't feel there are any significant leaks. Besides, I currently have a large full-face but I am switching to a medium.
5. I'm exercising regularly and eating pretty healthy (hence loss of weight). I'm avoiding coffee/tea anytime after 6 pm (and generally I don't even drink coffee/tea). Most of the time no liquor either.
My thought is to maybe adjust the pressure settings first? Any suggestions would be welcomed.
Basic Machine Info
Philips Respironics System One (60 Series)
RemStar BiPAP Auto with Bi-FlexModel 760P
PAP Mode: Auto Bi-Level (Variable PS)
Min EPAP 10.5 Max IPAP 15.5 PS 0.5-1.5 (cmH2O)
Detailed Machine Settings
PAP ModePAP Device Mode Auto Bi-Level (Variable PS)
Min EPAPLower Expiratory Pressure 10.50 cmH2O
Max EPAPHigher Expiratory Pressure 15.50 cmH2O
Min IPAPLower Inspiratory Pressure 11.00 cmH2O
Max IPAPHigher Inspiratory Pressure 15.50 cmH2O
PS MinPressure Support Minimum 0.50 cmH2O
PS MaxPressure Support Maximum 1.50 cmH2O
Flex LevelPRS1 pressure relief setting. x3
Flex ModePRS1 pressure relief mode. Bi-Flex
Headed TubingHeated Tubing Connected No
Humid. Lvl.PRS1 Humidification level x5
Humidifier StatusPRS1 humidifier connected? Connected
Ramp PressureStarting Ramp Pressure 4.00 cmH2O
Ramp TimeRamp Delay Period 30.00 Minutes