Re: Sleep Debt...
Posted: Thu Dec 16, 2010 12:04 am
I tend to think that the concept of "sleep debt" is a bit overstated. Certainly, if one misses a lot of sleep for several days, we need to catch up on "z"s.
However, for longer term (months, years) sleep deprivation and chronic intermittent hypoxia due to OSA, I suspect that we are looking more at physiological damage, primarily from oxidative and inflammatory processes.
The tissue damage (and resulting swelling, irritation, sleepiness, and feeling yucky) comes from local (like around the upper airway) and systemic (all over, every cell) inflammation. And, OSA is a prize-winner at causing inflammation. Among the messenger chemicals leading to inflammation and also the marker chemicals showing inflammation are TNF-[alpha], leukotrienes, reactive oxygen compounds, interleukin-6, and C-reactive protein. There are more.
So, when you treat the OSA with xPAP, you remove (many or most) of the inflammation causes, and after a while, much of the inflammation can subside.
Thus, I don't view xPAP therapy as repaying a debt; rather I look at it as removing a long list of chemical insults that our bodies produce as a result of endless bouts of near-suffocation. Once these stressors are removed, some things snap back right away, others take more time. Cellular damage takes some time to repair (and, hopefully, the repairs are eventually fairly complete.)
.
However, for longer term (months, years) sleep deprivation and chronic intermittent hypoxia due to OSA, I suspect that we are looking more at physiological damage, primarily from oxidative and inflammatory processes.
The tissue damage (and resulting swelling, irritation, sleepiness, and feeling yucky) comes from local (like around the upper airway) and systemic (all over, every cell) inflammation. And, OSA is a prize-winner at causing inflammation. Among the messenger chemicals leading to inflammation and also the marker chemicals showing inflammation are TNF-[alpha], leukotrienes, reactive oxygen compounds, interleukin-6, and C-reactive protein. There are more.
So, when you treat the OSA with xPAP, you remove (many or most) of the inflammation causes, and after a while, much of the inflammation can subside.
Thus, I don't view xPAP therapy as repaying a debt; rather I look at it as removing a long list of chemical insults that our bodies produce as a result of endless bouts of near-suffocation. Once these stressors are removed, some things snap back right away, others take more time. Cellular damage takes some time to repair (and, hopefully, the repairs are eventually fairly complete.)
.