https://jamanetwork.com/journals/jamane ... le/2791455
Findings In this randomized clinical trial involving 89 Spanish men with moderate to severe OSA who had overweight or obesity and were receiving CPAP therapy, an 8-week interdisciplinary weight loss and lifestyle intervention significantly improved OSA severity and other outcomes compared with usual care alone.
the intervention was conducted for 8 weeks and comprised 5 components or modules: nutritional behavior change, moderate aerobic exercise, smoking cessation, alcohol intake avoidance, and sleep hygiene. Each component included group-based weekly sessions of 60 to 90 minutes that were led and supervised by trained professionals (A.C.-B., F.J.A.-G., and L.J.-F.) in each field. Participants in the intervention group also continued to receive usual care with CPAP therapy. A detailed intervention description, including assessment of intervention adherence and integrity, has previously been published and is also provided in eMethods 3 and eMethods 4 in Supplement 2.
The claim that 10 of 34 participants at 6 months follow-up had complete OSA remission is wild.A main limitation is the sole inclusion of men in the study sample; the generalization of our findings is therefore limited to this population. The sample also included only Spanish participants; thus, our results are restricted to this ethnic population. Although this study included a 6-month follow-up assessment, the study’s duration may not have been sufficient to determine long-term intervention effects and maintenance of benefits. Due to ethical considerations, we did not include any group for whom no therapy was provided; CPAP therapy is the standard of care for moderate to severe OSA, and the inclusion of a group not receiving CPAP therapy may not be feasible.