Janknitz wrote:Here's Dr. Marty Kendall's take on all the squacking about Repatha: https://drmalcolmkendrick.org/2017/03/2 ... en-or-not/•The total number of deaths from cardiovascular disease in the Repatha group was 251
•The total number of deaths from cardiovascular disease in the placebo group was 240
•So, 11 more people died of cardiovascular disease in the Repatha group
The overall mortality data
•The total number of, overall, deaths in the Repatha group was 444
•The total number of, overall, deaths in the placebo group was 426
•So, there were 18 more deaths in those taking Repatha.
The differences here are not large enough to be statistically significant. However, there were more, not less, deaths in the Repatha group, and more, not less, CV deaths. This study was also terminated early, which is extremely bad news for any clinical trial, and casts enormous doubt on any findings. It was supposed to last four years, but was stopped at 2.2 years. Why? Were the mortality curves heading rapidly in the wrong direction.
Once again, drug companies conflate lower cholesterol with lower risk. It AIN'T so.
Thanks, Jan. So, I guess we can put those screaming headlines proclaiming the benefits of Repatha into the category of "fake news"!