COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

General Discussion on any topic relating to CPAP and/or Sleep Apnea.
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zonker
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by zonker » Sun May 17, 2020 7:11 pm

babydinosnoreless wrote:
Sun May 17, 2020 6:13 pm


:lol: :lol: hubby and I were co sysops for a bbs back in the 80's and into the early 90's.
i was only ever a lowly sysop on one of those hobbyist boards. best thing that ever happened to us(besides compuserve) was fidonet.

i'm much impressed by your cred!
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DreamDiver
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by DreamDiver » Sun May 17, 2020 7:17 pm


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babydinosnoreless
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by babydinosnoreless » Sun May 17, 2020 7:40 pm

zonker wrote:
Sun May 17, 2020 7:11 pm
babydinosnoreless wrote:
Sun May 17, 2020 6:13 pm


:lol: :lol: hubby and I were co sysops for a bbs back in the 80's and into the early 90's.
i was only ever a lowly sysop on one of those hobbyist boards. best thing that ever happened to us(besides compuserve) was fidonet.

i'm much impressed by your cred!

notworthy.gif
Don't be impressed it was definitely a hobby bbs. One of the larger ones here but Arizona was definitely behind the curve compared to the west coast. Remember the old modems and the tones they made when connecting. Our friend who owned the bbs had a bird who would perfectly mimic those tones. It was so funny.

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babydinosnoreless
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by babydinosnoreless » Sun May 17, 2020 7:57 pm

We (Arizona) opened Friday. I drove past one of our indian casinos today on my way back from Vegas and the parking lot was packed. I've never seen it so full. Vegas casinos are still shut down so I guess everyone came here. I am surprised with how hard the navajos are being hit that the other tribes aren't locked down. I also have to laugh at the map showing nevada as social distancing. Sure they are. :roll: They just came here cause their governor is a jerk.

weiss27md
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by weiss27md » Mon May 18, 2020 6:01 am

I'm curious. They say people can get infected twice from this virus so how would a vaccine help?

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ChicagoGranny
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by ChicagoGranny » Mon May 18, 2020 7:25 am

weiss27md wrote:
Mon May 18, 2020 6:01 am
I'm curious. They say people can get infected twice from this virus so how would a vaccine help?


Look at this study:
In one study on convalescent patients in China, 30% of those studied had very little or no detectable antibodies in their blood plasma. It would seem that those people were able to neutralize the infection without the need to develop antibodies, either because their innate immune response or the T cells in their adaptive immune response, or a combination of both, were sufficient. Those with the lowest counts of antibodies were most likely to be the youngest patients.
https://www.medrxiv.org/content/10.1101 ... 20047365v2
So, some people neutralized the infection without producing antibodies. This leaves open the possibility of catching it again. If their immune system is still in the same condition, they may well easily neutralize the second infection. Much of this depends on the dosage of the virus that entered their body.

Now, back to your question. Candidate vaccines are studied to see how large the dosage needs to be to cause the patient's immune system to create enough antibodies for immunity.

Of course, the effectiveness of any of the 100 or so vaccines in development is not known at this point. (The Oxford vaccine has shown some very promising results in monkeys.)

Also not known is how long the average recovered (unvaccinated) patient has enough antibodies to prevent a second case.

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DreamDiver
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by DreamDiver » Mon May 18, 2020 8:12 am

weiss27md wrote:
Mon May 18, 2020 6:01 am
I'm curious. They say people can get infected twice from this virus so how would a vaccine help?
Short answer: It may help by keeping people from dying from known strains when a vaccine becomes available. It may not help if the virus can mutate faster than new vaccines can be made. We don't know yet.

Long answer:

Viruses can be mutable. Some mutate very slowly. Others mutate quickly.

An example virus that's fairly mutable is the flu or influenza. It mutates to between one and three varieties in any given year, so the flu vaccine you got last fall may not work well for the flu variant that's coming next fall. However, because we're very familiar with flu, vaccines can be made for new variants a lot faster than can be made for a novel virus like SARS-COV2, the virus responsible for the disease Covid-19. We don't know enough about this virus to make a vaccine quickly.

A vaccine is basically like creating a code or hack for the immune system to tell the body what the enemy is before it can make a beachhead. If the vaccine is made incorrectly, it could cause the body to fight it's own cells. It would be bad if the cure is worse than the cause. That's why it takes so long to come up with a vaccine for a novel/new virus.

Since December I've heard that there are at least 3 variants already. It may be more mutable than the flu. If this is the case, it makes SARS-COV2 worse. Why? It has an R0 (contagion) value of about 2.5. With a higher mutability rate and a higher contagion rate, the likelihood of getting it again seems high. Worse, it still can kill you the second time. If it is found to be very mutable, there is a remote possibility that we will never be able to create a vaccine to kill it at all. In which case, travel of any kind means increasing likelihood of death.

This was stopped with the SARS and MERS viruses earlier in this century because we had a pandemic task force in place. The virus never hit large cities where it could establish itself in the general population. If we had known enough about flu way back in 1918, we could have stopped it from ever getting into the general population too. But now we live with flu. Thousands of people actually die every year from flu, but we've learned to live with it as an acceptable loss. Life goes on?

Now we have something much worse than the flu. It kills hundreds of thousands in a year, even when we're supposedly social distancing. Rest assured, it would have been far worse if we hadn't voluntarily sheltered in place and started using masks. Since we no longer have a pandemic task force, that layer of protection is gone. New and novel viruses used to be stopped every year or so. Again, SARS, MERS, Ebola... All of these were stopped with quarantine, contact tracing and testing before they got into the general population because of our pandemic task force. At the same time I rest uneasy because the resources that stopped new viruses before are gone. There's no telling what the next virus will be like. We could see something mild like the flu. We could see something worse than SARS-COV2. This all layered on top of our, now, two highly contagious gen-pop viruses, flu and SARS-COV2.

All of this could be stopped in three months if we all just hunkered down, everywhere in every home for three months, globally. Our economic system and governments aren't set up for that. We rely on long-distance trade and travel for the conveniences we love. It's hard to give that up, even for three months. Just three months of everyone simply not moving would slow down a lot of diseases. But we're not doing that. We're still moving around. So the virus will find a sustainable enviromnent and "live" with us, killing just enough of us that we'll grow used to the new acceptable loss, just like before we had vaccines. It's almost like Mother Nature is intentionally finding ways to reduce our population because we're not doing it ourselves. It was bound to happen. Here it is, made manifest. This is the zombie apocalypse your government pandemic task force warned you about.

Life as we know it has changed all because of one virus in the general population. Try not to imagine what it will be like with the next novel virus.

Chris

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Last edited by DreamDiver on Mon May 18, 2020 9:24 am, edited 2 times in total.
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jnk...
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by jnk... » Mon May 18, 2020 8:57 am

Thanks, Chris. Well put, IMO.
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Dog Slobber
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by Dog Slobber » Mon May 18, 2020 9:14 am

weiss27md wrote:
Mon May 18, 2020 6:01 am
I'm curious. They say people can get infected twice from this virus so how would a vaccine help?
If all one is going to post with a "They say" and then asserting some claim, don't even post. It is these types of posts that are responsible for all the misinformation so prevalent in modern day society.

If no source is provided, don't believe it and certainly don't spread it.

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chunkyfrog
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by chunkyfrog » Mon May 18, 2020 10:05 am

It seems that the key to degree of infection is the degree of EXPOSURE.
In this case., distance and any old mask might make the difference
between hardly any infection and pushing up daisies.

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jnk...
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by jnk... » Mon May 18, 2020 10:40 am

Dog Slobber wrote:
Mon May 18, 2020 9:14 am
weiss27md wrote:
Mon May 18, 2020 6:01 am
I'm curious. They say people can get infected twice from this virus so how would a vaccine help?
If all one is going to post with a "They say" and then asserting some claim, don't even post. It is these types of posts that are responsible for all the misinformation so prevalent in modern day society.

If no source is provided, don't believe it and certainly don't spread it.
Poster asserted no claim. Poster asked a question. It is those types of posts that help fight the spread of misinformation. Your response could be considered less than welcoming and less than helpful to a helpful question from someone seeking help. Just my opinion. Something overheard often sparks healthy curiosity, which was what the poster was expressing.

Here is a relevant statement from Mayo ten days ago (the first mention of "coronoviruses" refers to other ones previously known):
After infection with coronaviruses, re-infection with the same virus — though usually mild and only happening in a fraction of people — is possible after a period of months or years. An effective COVID-19 vaccine will need to provide people with long-term infection protection.--https://www.mayoclinic.org/diseases-con ... t-20484859
This information, from 11 days ago, may also be relevant to the poster's question:
"Unfortunately, we cannot really generalize what kind of immunity is needed to get protection against a virus unless we really learn more about the virus," says Akiko Iwasaki, a Howard Hughes Medical Institute investigator at the Yale University School of Medicine.--https://www.npr.org/sections/health-sho ... einfection
And published today, speaking of antibody testing only, not specifically vaccines:
The scientific community is still working to understand what level of antibodies might be needed for protection from reinfection with COVID-19, and how long that protection might last.--https://www.biospace.com/article/releas ... or-groups/
-Jeff (AS10/P30i)

Accounts to put on the foe list: Me. I often post misleading, timewasting stuff.

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Dog Slobber
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by Dog Slobber » Mon May 18, 2020 11:31 am

jnk... wrote:
Mon May 18, 2020 10:40 am
Dog Slobber wrote:
Mon May 18, 2020 9:14 am
weiss27md wrote:
Mon May 18, 2020 6:01 am
I'm curious. They say people can get infected twice from this virus so how would a vaccine help?
If all one is going to post with a "They say" and then asserting some claim, don't even post. It is these types of posts that are responsible for all the misinformation so prevalent in modern day society.

If no source is provided, don't believe it and certainly don't spread it.
Poster asserted no claim. Poster asked a question. It is those types of posts that help fight the spread of misinformation. Your response could be considered less than welcoming and less than helpful to a helpful question from someone seeking help. Just my opinion. Something overheard often sparks healthy curiosity, which was what the poster was expressing.

"They say people can get infected twice from this virus....."

people can get infected twice, is an assertion.

And yes, questions can help spread misinformation, but the question should have targeted the assertion, not the response to the assertion.

And sometimes questions are not questions, they too can be assertions.

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zonker
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by zonker » Mon May 18, 2020 11:46 am

very early days, but-

US drugmaker reports promising early results from COVID-19 vaccine test

https://www.rawstory.com/2020/05/us-dru ... cine-test/
people say i'm self absorbed.
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Dog Slobber
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by Dog Slobber » Mon May 18, 2020 12:04 pm

zonker wrote:
Mon May 18, 2020 11:46 am
...
I'm curious. They say there's a vaccine from this virus so where do I get one?

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ChicagoGranny
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Re: COVID 19, CPAP, Ventilator MEGA THREAD...everything go here please

Post by ChicagoGranny » Mon May 18, 2020 12:12 pm

zonker wrote:
Mon May 18, 2020 11:46 am
very early days, but-

US drugmaker reports promising early results from COVID-19 vaccine test

https://www.rawstory.com/2020/05/us-dru ... cine-test/
Thanks for posting that encouraging report. I was down after just reading this shade thrown on the Oxford vaccine --->
Did The Oxford Covid Vaccine Work In Monkeys? Not Really
William A. Haseltine


https://www.forbes.com/sites/williamhas ... 9975903c71