Preventing Heart Attacks and Strokes w/cpap (new research)

[RosemaryB]

http://tinyurl.com/2sv3dk

NEW YORK, N.Y. -- September 28, 2007 -- Researchers in Brazil have found that treating patients who suffer from obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) dramatically reduces early indications of atherosclerosis in just months, linking OSA directly to the hardening or narrowing of the arteries. Until now, no study has demonstrated such a direct relationship between the two.

"OSA is independently associated with increased risk of fatal cardiovascular events that can be reversed by treatment with CPAP," wrote Luciano Drager, MD, of the University of São Paulo Medical School in Brazil.

The research was published in the first issue of the American Journal of Respiratory and Critical Care Medicine for October of 2007, published by the American Thoracic Society.

I'm planning on taking this article to my doctor next time I see him.

[gulfpearl]

Thank you for this informative article. It is so appropiate my mother is in ICU recovering from a stroke caused by atheroscclerosis of her cartoid artery. Her's was 99% occluded. While in ICU the nurses tried to talk her into getting a sleep study due to her snoring & O2 desats. Her anwser to them was not to bother she would never sleep with that damn machine. I guess I have to go into overdrive to convince her to get a sleep study & if need be cpap usage. I don't know how she can be so stubborn when she has seen how much the cpap has helped my sister & I. I sent this article to my sister to try to convince her.

[Windfall]

Awesome! Thank you for posting this article.

[Gerald]

Gulfpearl....

Tell your mother that her sleep without the "damn machine" will be VERY deep......and that you'd appreciate her getting the will prepared....so that the mess you have to clean up will be minimal.

Her ICU visit was a warning. She has a 2nd chance.

[Snoredog]

http://tinyurl.com/2sv3dk

NEW YORK, N.Y. -- September 28, 2007 -- Researchers in Brazil have found that treating patients who suffer from obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) dramatically reduces early indications of atherosclerosis in just months, linking OSA directly to the hardening or narrowing of the arteries. Until now, no study has demonstrated such a direct relationship between the two.

"OSA is independently associated with increased risk of fatal cardiovascular events that can be reversed by treatment with CPAP," wrote Luciano Drager, MD, of the University of São Paulo Medical School in Brazil.

The research was published in the first issue of the American Journal of Respiratory and Critical Care Medicine for October of 2007, published by the American Thoracic Society.

I'm planning on taking this article to my doctor next time I see him.

[RosemaryB]

[quote="gulfpearl"]Thank you for this informative article. It is so appropiate my mother is in ICU recovering from a stroke caused by atheroscclerosis of her cartoid artery. Her's was 99% occluded. While in ICU the nurses tried to talk her into getting a sleep study due to her snoring & O2 desats. Her anwser to them was not to bother she would never sleep with that damn machine. I guess I have to go into overdrive to convince her to get a sleep study & if need be cpap usage. I don't know how she can be so stubborn when she has seen how much the cpap has helped my sister & I. I sent this article to my sister to try to convince her.

[RosemaryB]

http://tinyurl.com/2sv3dk

NEW YORK, N.Y. -- September 28, 2007 -- Researchers in Brazil have found that treating patients who suffer from obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) dramatically reduces early indications of atherosclerosis in just months, linking OSA directly to the hardening or narrowing of the arteries. Until now, no study has demonstrated such a direct relationship between the two.

"OSA is independently associated with increased risk of fatal cardiovascular events that can be reversed by treatment with CPAP," wrote Luciano Drager, MD, of the University of São Paulo Medical School in Brazil.

The research was published in the first issue of the American Journal of Respiratory and Critical Care Medicine for October of 2007, published by the American Thoracic Society.

I'm planning on taking this article to my doctor next time I see him.

[Moby]

I managed to access the full research article online through my work library.

Can't copy it here because of copywrite laws.

Do have it on Word though.



I wouldn't have agreed to a four month wait for a cpap once I'd been diagnosed. They can't do a longer trial for ethical reasons, they imply they would have had much more data if they had.


Initially I wondered at the small number of study participants. They screened 400 men but found only 24 with no existing clinical indicators of artery disease. I think that is important as it appears to confirm that OSA is a risk in itself - something that sets off the downward spiral into high Bp, high cholesterol, obesity, that we are all so familiar with.


The study suggests that early detection and treatment of SA is important in preventing these conditions. We all know that, but it's good to have the medical field really thinking along the lines that SA is the cause rather than the effect.

My husband works in the biostat field. I'll get him to look at it tonight.

Di

[lilsheba]

Geeze it's articles like that that make me really glad I got the diagnosis and the treatment. It's scary to think I could have gone on god knows how long with OSA and the consequences.

[Snoredog]

Here are some of my links I used when I studied it a few years back, it is all related to inflammation which seems to be the bad guy, many of those links are probably no longer valid:

http://www.medicalnewstoday.com/articles/30001.php

my favorite is Professor Ed's Pathology site, his site is hard to follow and corny, but if you can find it he explains the etiology behind the effects of hypoxia, what it does to the cells that make up the lining of your arteries which triggers this whole inflammation process, what enzymes get released, how platelets are aggregated etc. The role of cholesterol in the blood stream when inflammation is present.
He says it is much easier to study you after you are dead

http://www.pathguy.com/lectures/inflamma.htm

http://www.tandf.co.uk/journals/titles/09629351.html
http://www.atherothrombosis.org/public/index.html
http://www.clevelandclinic.org/heartcen ... irdCat=568
http://medweb.bham.ac.uk/http/depts/pat ... ronic.html
http://www.medicalnewstoday.com/medical ... wsid=30001
http://www.egregore.com/diseases/infect ... tions.html
http://www.pathguy.com/lectures/inflamma.htm
http://www.nutramed.com/immunology/inflammation.htm
http://www.int-med.uiowa.edu/research/I ... ation.html
http://www.ciir.qub.ac.uk/
http://medlib.med.utah.edu/WebPath/INFL ... FL066.html
http://www.msnbc.com/news/834632.asp?cp1=1
http://medlib.med.utah.edu/WebPath/INFL ... FL065.html
http://www.lipidsonline.org/slides/slid ... flammation
http://www.mlnm.com/rd/inflammation/index.asp
http://www.nature.com/nature/insights/6917.html
http://www.rheumatoidarthritis-academy. ... mation.htm
http://www.gla.ac.uk/departments/immunology/
http://www.mayoclinic.com/health/arteri ... is/DS00525

[Guest]

SNOREDOG & ROSEMARYB, you two never seek to amaze me, thank you both soooooo much for the info and links.. And I do hope that she can convince her Mom before it's to late, however alot of people choose to just let the bad things happen to them rather than getting any treatment.. It's kind of like the saying " WHATEVER WILL BE WILL BE " !! I want to live as long as I can without any strokes , heart attacks, etc., and with cpap the good outweighs the bad by far...... Once again, I am so thankful for this forum and for all of you and your great knowledge ! SleepyNoMore

[Moby]

Thanks Snoredog.

Some PubMed links, hope they work
Probably just the abstracts, may be able to access the full paper in some.

http://shorl.com/fifrabypyvohy

or

http://www.ncbi.nlm.nih.gov.qelibresour ... d=15901608

[Snoredog]

Thanks Snoredog.

Some PubMed links, hope they work
Probably just the abstracts, may be able to access the full paper in some.

http://shorl.com/fifrabypyvohy

or

http://www.ncbi.nlm.nih.gov.qelibresour ... d=15901608

If you click on the last one from the mayo, it is pretty good at explaining it but it doesn't provide the missing hypoxia link. One of the other links does, can't remember which one.

When I say I have been saying what that study revealed for years it is because I had studied and read it in one of those papers (those links are just a paste from my Safari browser for Arteriosclerosis / Atherosclerosis.

Is that same inflammation the cause of arthritis?

Who knows (aaahhh as I'm typing this I'm getting a niacin rush/flush from a 500mg Niacin tablet I take before bed). It is OTC niacin so it is not buffered and it hits you all at once, I've grown used to it so it only lasts about a minute. I used to take Niaspan as it was timed release and doesn't give all that flushing.

[Guest]

Hi,

I watched a documentary tv show called "medical...." regarding challenges faced by doctors. There was an old man was 82+ too old to take the risk of liver sugery and the doctor had to tell him of their decision for not to operate on him and had to let him die slowly, it was very sad. Well, I remembered what the old man said "like the old saying.....everybody wants to go to heaven but nobody wants to die".....something that I felt deep inside as I pray for all those run out of time.

The great wisdom from the old man said "like the old saying.....everybody wants to go to heaven but nobody wants to die".

Mckooi