New Research for Sleep Apnea from NIH

General Discussion on any topic relating to CPAP and/or Sleep Apnea.
D.H.
Posts: 3467
Joined: Sun Sep 04, 2016 7:07 pm

Re: New Research for Sleep Apnea from NIH

Post by D.H. » Thu Mar 16, 2017 6:54 pm

CPAP is one of the lowest risk medical interventions around! Of course, it's not zero risk, but it's as close as medicine comes!

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Additional Comments: Auto PAP; 13.5 cmH2O min - 20 cmH2O max

gus80
Posts: 1
Joined: Mon Oct 14, 2019 7:39 am

Re: New Research for Sleep Apnea from NIH

Post by gus80 » Mon Oct 14, 2019 8:05 am

DeeCPAP wrote:
Sat Feb 25, 2017 5:46 pm
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NOTE: Below is a link to the study funded by the National Institute of Health -- (NIH) a very credible source of information.

Maybe someone here knows something about Yohimbine, an herb. I just checked and it's sold over-the-counter, but please read the article first. I'd do almost anything not to struggle with a CPAP machine.

LINK:
https://scienceblog.com/492417/dietary- ... eep-apnea/
Hello friends. I'm 38, I discovered apnea at 28. I have no changes in airway obstruction and was thin when I found out. I have reversal of the circadian cycle, ADHD, chronic insomnia, since the age of 15.

As you may have read, thin sleep apnea patients have great difficulty using cpap. This is my case.

I recently went to a nutrologist and endocrinologist to try to lose weight, as 25 years of bad sleep put on weight, and trying to sleep better too.

He gave me some supplements that decrease cortisol and glutamate (we know both are increased in sleep apnea patients), such as Relora, Taurine, Gaba. To aid both brain and weight loss, he put me on a ketogenic diet and prescribed me yohimbine.

Like most users of this forum, I have learned to research everything I can and try to come across my symptoms. That's exactly what I did in the case of supplements. My biggest surprise was really with yohimbine, which as an alpha adrenergic antagonist, positively affects both the hypoglossal contraction and helps regulate the sleep-wake cycle.

So I showed the scientific articles to my doctor, who was unaware of such a relationship, and we agreed to perform tests. I have been taking 5mg of yohimbine hcl for a week before going to bed. Surprisingly I'm sleepy between 21 and 23 hours and I'm getting to sleep all night and wake up spontaneously between 6 and 7 am. I point out that this had not happened in 25 years. I am more rested during the day, still far from ideal, but along with a daytime stimulant such as ritalin or red bull, I can act almost like a normal person.

I write this so that we can exchange information on the evolution of this research and personal testing. Below are some links to scientific articles to complement those already posted. In the same vein are currently testing Atomoxetine and Oxybutynin
in Obstructive Sleep Apnea, which are adrenergic and cholinergic antagonists. Just like yohimbina.

The tests on rats were done with 0.2 to 1mg / kg, however in humans, 05mg / kg corresponds to 5.6mg for a 70kg person. I have been using 5mg, as I am 90kg currently, I will increase to 7.5mg to test. If there is interest, I can report the progress.

Unfortunately we know that many patients do not adapt well to cpap, would love if I were one who can sleep with the device and lessen the impact that sleep apnea brings to our lives. But unfortunately I am not. I hope that those who cannot find solution via cpap will be interested in the topic.






https://patentimages.storage.googleapis ... 1319A1.pdf

https://www.frontiersin.org/articles/10 ... 00752/full

https://www.ncbi.nlm.nih.gov/pubmed/28239660

https://www.ncbi.nlm.nih.gov/pubmed/7557820

https://www.ncbi.nlm.nih.gov/pubmed/9639274

https://clinicaltrials.gov/ProvidedDocs ... AP_000.pdf